Lack of antimicrobial activity of sodium heparin for treating experimental catheter-related infection due to Staphylococcus aureus using the antibiotic-lock.

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Lack of antimicrobial activity of sodium heparin for treating experimental catheter-related infection due to Staphylococcus aureus using the antibiotic-lock technique  J.A. Capdevila, J. Gavaldà, J. Fortea, P. López, M.T. Martin, X. Gomis, A. Pahissa  Clinical Microbiology and Infection  Volume 7, Issue 4, Pages 206-212 (April 2001) DOI: 10.1046/j.1469-0691.2001.00233.x Copyright © 2001 European Society of Clinical Infectious Diseases Terms and Conditions

Figure 1 Time-kill curves of the strains used in the in vivo studies. S. aureus D 22.1 (A) and N 16.2 (B). Sodium heparin at 2500 UI/mL, vancomycin at 0.25 mg/L (A) and 2 mg/L (B), ciprofloxacin at 0.25 mg/L (A, B). •, Control; ∘, heparin 2500; ▴, vancomycin MIC; ♦, ciprofloxacin MIC; *, vancomycin + heparin; □, ciprofloxacin + heparin. Clinical Microbiology and Infection 2001 7, 206-212DOI: (10.1046/j.1469-0691.2001.00233.x) Copyright © 2001 European Society of Clinical Infectious Diseases Terms and Conditions