Volume 140, Issue 1, Pages 153-161 (January 2011) Type of CFTR Mutation Determines Risk of Pancreatitis in Patients With Cystic Fibrosis  Chee Y. Ooi, Ruslan Dorfman, Marco Cipolli, Tanja Gonska, Carlo Castellani, Katherine Keenan, Steven D. Freedman, Julian Zielenski, Yves Berthiaume, Mary Corey, Susanne Schibli, Elizabeth Tullis, Peter R. Durie  Gastroenterology  Volume 140, Issue 1, Pages 153-161 (January 2011) DOI: 10.1053/j.gastro.2010.09.046 Copyright © 2011 AGA Institute Terms and Conditions

Figure 1 Survival curves comparing time to pancreatitis in patients grouped according to severity of CFTR genotype. (A) Kaplan–Meier estimate of the proportion of patients with PS-CF who have not developed pancreatitis through to the age of 50 years for mild and severe CFTR genotype groups. (B) Kaplan–Meier estimate of the proportion of patients with PS-CF who have not developed pancreatitis through to the age of 50 years stratified according to the severity of both CFTR alleles. The survival tables (below each curve) indicate the number of patients/“survivors” at risk for pancreatitis at 0, 10, 20, 30, 40, and 50 years, respectively. Gastroenterology 2011 140, 153-161DOI: (10.1053/j.gastro.2010.09.046) Copyright © 2011 AGA Institute Terms and Conditions

Figure 2 A conceptual model demonstrating CFTR-related factors that contribute to pancreatitis. Development of pancreatitis is associated with the opposing factors of severity of ductal obstruction and degree of pancreatic acinar reserve (see text for details). Gastroenterology 2011 140, 153-161DOI: (10.1053/j.gastro.2010.09.046) Copyright © 2011 AGA Institute Terms and Conditions