New generation of anti-target drug: small interfering RNA 1990 Napoli C, Lemieux C, Jorgensen R. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous gene in trans. Plant Cell 1990;2:279-89 1995 Guo S, and Kemphues KJ. par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell 1995 May 19;81(4):611-20.1998 2001 Bernstein et al. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 2001 Jan 18;409(6818):363-6 Elbashir et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494-8 2002 Jiang M, Milner J. Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference. Oncogene 2002;21:6041-8 McCaffrey et al. RNA interference in adult mice. Nature 2002;418 (6893): 38-9 2003 Song et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med. 2003 Mar;9(3):347-51 Small interfering RNA (siRNA), sometimes known as short interfering RNA or silencing RNA, is a class of double-stranded RNA molecules, 20-25 nucleotides in length, that play a variety of roles in biology. The most notable role of siRNA is its involvement in the RNA interference (RNAi) pathway, where it interferes with the expression of a specific gene. Yi-Da Kang , born in Taiwan on Aug. 15, 1986. I am currently a master student at the Institute of Optoelectronic Sciences at National Taiwan Ocean University. My major is lithography, biomaterial, x-ray synthesis, 3-D image reconstructed. E-mail:19988032@mail.ntou.edu.tw