Differential response of placebo treatments in osteoarthritis trials: a systematic review and network meta-analysis R.R. Bannuru, C.H. Schmid, M.C. Sullivan,

Slides:

Advertisements

Similar presentations

Comparative efficacy of oral non-steroidal anti-inflammatory drugs and opioids for osteoarthritis: Systematic review and meta-analysis S.R. Smith, B.R.

Advertisements

Electrical stimulation for pain relief in knee osteoarthritis: systematic review and network meta-analysis C. Zeng, H. li, T. Yang, Z.-h. Deng, Y. Yang,

T. E. McAlindon, R. R. Bannuru, M. C. Sullivan, N. K. Arden, F

Electrical stimulation for pain relief in knee osteoarthritis: systematic review and network meta-analysis C. Zeng, H. li, T. Yang, Z.-h. Deng, Y. Yang,

Change in knee osteoarthritis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging following treatment with collagen hydrolysate:

T. E. McAlindon, R. R. Bannuru, M. C. Sullivan, N. K. Arden, F

A. Bhave, M. Mont, M. Chugthai, R. Starr Osteoarthritis and Cartilage

R. Takeuchi, H. Ishikawa, T. Kuniya, A. Nakazawa

K.S. Santangelo Osteoarthritis and Cartilage

S. Gavard Osteoarthritis and Cartilage

Isotropic three-dimensional T2 mapping of knee cartilage with T2-prepared segmented gradient ECHO at 3T R. Colotti, P. Omoumi, R.B. van Heeswijk Osteoarthritis.

Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis M. Chung, N. Zhao, J.B. Wong, C. Wang Osteoarthritis.

Does land-based exercise reduce pain and disability associated with hip osteoarthritis? A meta-analysis of randomized controlled trials M. Fransen, S.

Quantitatively-measured bone marrow lesions in the patellofemoral joint: distribution and association with pain C. Ratzlaff, R. Russell, J. Duryea Osteoarthritis.

Role of endothelin-1 in endochondral ossification and osteoarthritis

Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim

G. Venne, S. Pang, Y. Tse, R. Ellis Osteoarthritis and Cartilage

Effect of mechanical stress on the hypertrophic differentiation related gene expression in cultured chondrocytes H. Inoue, Y. Arai, R. Terauchi, S. Nakagawa,

Evaluation of TRB-n0224, a Chemically Modified Curcumin for the Treatment of Osteoarthritis R. Nixon, J. Coury, S.S. Shah, N. Chahine, T. Goldstein,

Z. Zhang, W. Liao, Z. Zhang, X. Duan, C. Hou

Replicability of recommended exercise interventions for knee osteoarthritis: a descriptive systematic review of current clinical guidelines and recommendations

OARSI recommendations for the management of hip and knee osteoarthritis: the semantics of differences and changes T.E. McAlindon, R.R. Bannuru Osteoarthritis.

P. Yuan, X. Zhang, W. Yang, W. Kang, B. Yang, J. li, B. Chen, X. Li, B

Intra-articular corticosteroids may be a cost-effective strategy for short-term management of knee osteoarthritis R.R. Bannuru, J.B. Wong, D.M. Kent,

Association of ultrasound-defined structural changes with regional and diffuse knee pain patterns – Oulu Knee Osteoarthritis study J. Podlipská, P. Kaukinen,

Are bisphosphonates efficacious in knee osteoarthritis

T1rho and T2 Relaxation of Knee Articular Cartilage in Patients With and at Risk for Knee Osteoarthritis: A Systematic Review and Meta-Analysis H.F.

Anti-inflammatory Properties of SM04690, a Small Molecule Inhibitor of the Wnt Pathway as a Potential Treatment for Knee Osteoarthritis V. Deshmukh,

B. Vafaeian, S. Adeeb, M. El-Rich, J. Jaremko

The influence of early osteoarthritic collagen network de-structuring in articular cartilage on the tissue stiffness and swelling properties M. Nickien,

N. Bodick, J. Lufkin, C. Willwerth, A. Kumar, J. Bolognese, C

Effectiveness of thermal and athermal short-wave diathermy for the management of knee osteoarthritis: a systematic review and meta-analysis Y. Laufer,

Efficacy of low frequency pulsed subsensory threshold electrical stimulation vs placebo on pain and physical function in people with knee osteoarthritis:

A new lipid formulation of low dose (1200mg) ibuprofen is non-inferior to high dose (2400mg) standard ibuprofen capsules in managing episodic knee pain.

Y. Levy, A. Hasegawa, S. Patil, M. Lotz, D. D'Lima

Effect of soft braces on pain and physical function in patients with knee osteoarthritis: systematic review with meta-analyses T. Cudejko, M. van der.

M.N. Khan, M.Y. Ansari, T.M. Haqqi Osteoarthritis and Cartilage

Individuals with accelerated knee osteoarthritis have greater pain and functional impairments than individuals with common knee osteoarthritis: Data from.

Patellofemoral Bone Morphology is Related to Gender But Not Pain: 3D Quantitative Data Analysis From The OAI M.A. Bowes, B.T. Drew, A.C. Redmond, B.

Spontaneous home cage activity is sensitive to anti-NGF treatment or can be linked to joint stiffness in different models of surgery-induced osteoarthritis

Emerging role of endothelin receptor type B in regulating chondrogenic and hypertrophic changes of human mesenchymal stem cells M. Au, M. Zhu, W.-J.

Comparing clinical outcomes of exercise intervetions according to the American college of sports medicine guidelines for strength training to other types.

Z. Huang, T. Stabler, F. Pei, V. Kraus Osteoarthritis and Cartilage

Corrigendum to ‘2014 OARSI Guidelines for the Non-Surgical Management of Knee Osteoarthritis’ [Osteoarthritis and Cartilage 22 (2014) 363–388] T.E. McAlindon,

A systematic review of the efficacy and general safety of antibodies to NGF in the treatment of OA of the hip or knee T.J. Schnitzer, J.A. Marks Osteoarthritis.

Damps provide a link between joint tissue damage and pain through direct activation of TLR4 expressed by sensory neurons R.E. Miller, P.B. Tran, S. Ishihara,

Low-dose SoluMatrix meloxicam results in clinically meaningful improvements in pain in a phase 3 study of patients with osteoarthritis R. Altman, M.

Comparative efficacy of oral non-steroidal anti-inflammatory drugs and opioids for osteoarthritis: Systematic review and meta-analysis S.R. Smith, B.R.

Total knee replacement followed by a non-surgical treatment program reduce localized and spreading pain sensitization – A pre-defined ancillary analysis.

Evidence for bone mineral density and bone resorption in middle and elderly women with knee osteoarthritis in Shanghai: a cross sectional study Q. Xiaofeng

Walking with increased foot progression angle can reduce joint compression in individuals with knee OA K. Manal, T.S. Buchanan Osteoarthritis and Cartilage

Monocyte chemoattractant protein 1 induced chondrocytes degeneration and cartilage degradation in osteoarthritis X. yuankun, K. Yan, W. Bin, L. Jian-Hao

Individuals with severe knee OA are at increased risk of all-cause and cardiovascular disease-specific mortality: The johnston county osteoarthritis project

Therapeutic trajectory following intra-articular hyaluronic acid injection in knee osteoarthritis – meta-analysis R.R. Bannuru, N.S. Natov, U.R. Dasi,

Multivariate pattern analysis of physical activity and cartilage health: data from the osteoarthritis initiative E. Halilaj, T.J. Hastie, G.E. Gold,

Osteoarthritis and Cartilage

Fracture severity predicts OA risk following intra-articular fractures

Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu

No treatment effects of oral glucosamine for subgroups of knee and hip osteoarthritis patients; an individual patient data meta-analysis from the OA trial.

The effect of quadriceps-strengthening exercise on quadriceps and knee biomichanics during walking in adults with knee osteoarthritis: a randomized controlled.

Coronal tibial slope is associated with incident accelerated knee osteoarthritis: data from the Osteoarthritis Initiative J.B. Driban, A.C. Stout, J.

Diclofenac not more effective than acetaminophen in patients with mild knee osteoarthritis: results of a randomized controlled trial in primary care with.

Pain and functional trajectories in symptomatic knee osteoarthritis over up to 12 weeks of exercise exposure A.C. Lee, W.F. Harvey, X. Han, L.L. Price,

Knee kinematic and kinetic modifications under body weight unloading during overground walking at a constant speed A.G. Fischer, E.M. Debbi, A. Wolf

Amyloid micronetworks for cartilage repair

Cross-sectional and longitudinal association between types of meniscal pathology and knee pain: Data from the osteoarthritis initiative B. Eathakkattu.

Quadriceps/Hamstrings co-activation during gait in individuals with anterior cruciate ligament reconstruction T. Blackburn, B. Pietrosimone, J. Goodwin,

A. Carlson, B. Bothner, R. June Osteoarthritis and Cartilage

General Information Osteoarthritis and Cartilage

Long-term effects of vitamin d supplementation and maintaining vitamin d sufficiency on knee osteoarthritis over 5 years B. Antony, S. Zheng, J. Burgess,

Presentation transcript:

Differential response of placebo treatments in osteoarthritis trials: a systematic review and network meta-analysis R.R. Bannuru, C.H. Schmid, M.C. Sullivan, D.M. Kent, J.B. Wong, T.E. McAlindon Osteoarthritis and Cartilage Volume 22, Pages S24-S25 (April 2014) DOI: 10.1016/j.joca.2014.02.068 Copyright © 2014 Terms and Conditions

Figure 1 Network of different placebo comparisons. Osteoarthritis and Cartilage 2014 22, S24-S25DOI: (10.1016/j.joca.2014.02.068) Copyright © 2014 Terms and Conditions

Figure 2 Standardized mean differences of active treatments for pain at 12 weeks comparing results from differential placebo effect network and single placebo effect network. Osteoarthritis and Cartilage 2014 22, S24-S25DOI: (10.1016/j.joca.2014.02.068) Copyright © 2014 Terms and Conditions

Figure 3 Standardized mean differences of active treatments for pain at 12 weeks comparing results from deferential placebo effect network and single placebo effect network Osteoarthritis and Cartilage 2014 22, S24-S25DOI: (10.1016/j.joca.2014.02.068) Copyright © 2014 Terms and Conditions