Autoantibodies against intercalated cells in Sjögren's syndrome

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Autoantibodies against intercalated cells in Sjögren's syndrome Olivier Devuyst, Matthieu Lemaire, Nilufar Mohebbi, Carsten A. Wagner Kidney International Volume 76, Issue 2, (July 2009) DOI: 10.1038/ki.2009.112 Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 1 Intercalated cells in Sjögren's syndrome. Immunostaining for H+-ATPase in normal human kidney (a) and the distal renal tubular acidosis (dRTA) patient (b, d), showing a decreased immunoreactivity in both the proximal tubule (pt) and collecting duct (cd) profiles. Staining for AQP2 on serial sections from the dRTA kidney (c, d) shows a lack of intercalated cells (ICs) positive for H+-ATPase in the collecting ducts. Panels (e) (semi-thin section, toluidine blue) and (f) (ultra-thin section, uranyl acetate and lead citrate) reveal apparently normal ICs in the dRTA kidney. Incubation of control human kidneys with immunoglobulin G (IgG) extracted from the dRTA patient stained ICs in collecting ducts (g, h: asterisks). The A-type ICs stained with the auto-antibodies (h) were positively identified on serial sections with apical H+-ATPase (i) and basolateral AE1 (j), whereas no signal was obtained with control human IgG (k). Immunostaining was performed as in Moulin et al.5 Original magnification (a–e, g) × 20; (h–k) × 40; (f) bar=2μm. Kidney International 2009 76, DOI: (10.1038/ki.2009.112) Copyright © 2009 International Society of Nephrology Terms and Conditions