Polymorphisms in Genes That Regulate Cyclosporine Metabolism Affect Cyclosporine Blood Levels and Clinical Outcomes in Patients Who Receive Allogeneic.

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Presentation transcript:

Polymorphisms in Genes That Regulate Cyclosporine Metabolism Affect Cyclosporine Blood Levels and Clinical Outcomes in Patients Who Receive Allogeneic Hematopoietic Stem Cell Transplantation Youngil Koh, Inho Kim, Dong-Yeop Shin, Ji-Yeon Bae, Hyun-Kyung Kim, Sung-Soo Yoon, Sung Sup Park, Dong Soon Lee, Seonyang Park, Byung Kook Kim Biology of Blood and Marrow Transplantation Volume 18, Issue 1, Pages 37-43 (January 2012) DOI: 10.1016/j.bbmt.2011.08.019 Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Associations between the CYP3A5 +6986 SNP and cyclosporine blood levels at day 1 and day 3. The CYP3A5 +6986AA genotype was associated with high cyclosporine blood levels at day 1 (A) and day 3 (B). Biology of Blood and Marrow Transplantation 2012 18, 37-43DOI: (10.1016/j.bbmt.2011.08.019) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Impact of the MDR1 +1236 SNP on the clinical outcome of patients who received allogeneic HSCT. When both the donor and the recipient did not possess the +267 CC genotype, patients experienced lower elevations in creatinine (A) and bilirubin (B), less TRM (C), and longer OS (D). ∗The bar designates mean value. In panels (A) and (B), the values that exceeded the y-axis maximum are not shown. Biology of Blood and Marrow Transplantation 2012 18, 37-43DOI: (10.1016/j.bbmt.2011.08.019) Copyright © 2012 American Society for Blood and Marrow Transplantation Terms and Conditions