GFR (mL/min per 1.73 m2) in high-risk renal transplant patients according to treatment Risk factor Treatment GFR at baseline GFR at 5 years p Cadaveric donor SRL + CsA 56.5 43.3 <0.001 SRL 55.3 57.5 0.273 Second transplant 55.5 38.9 0.011 52.4 46.7 0.239 Donor age >50 years 49.5 35.0 49.0 46.2 0.326 HLA mismatch ≥4 56.3 41.7 54.6 58.5 0.215 Acute rejection 46.6 27.1 0.012 41.6 0.099 Proteinuria 52.6 35.1 0.001 53.8 52.1 0.653 Legendre C et al. 12th Congress of the European Society for Organ Transplantation; October 15-19, 2005; Geneva, Switzerland.