Volume 73, Issue 9, Pages 1069-1081 (May 2008) Chronic kidney disease and postoperative mortality: A systematic review and meta- analysis A. Mathew, P.J. Devereaux, A. O'Hare, M. Tonelli, H. Thiessen-Philbrook, I.F.P. Nevis, A.V. Iansavichus, A.X. Garg Kidney International Volume 73, Issue 9, Pages 1069-1081 (May 2008) DOI: 10.1038/ki.2008.29 Copyright © 2008 International Society of Nephrology Terms and Conditions
Figure 1 Selection of studies.aDiscrete cohorts within one article are defined as separate studies. bStudies were excluded as the first criteria was met. cNo matching of key patient characteristics, lack of adjustment in data analysis. Kidney International 2008 73, 1069-1081DOI: (10.1038/ki.2008.29) Copyright © 2008 International Society of Nephrology Terms and Conditions
Figure 2 Risk of postoperative mortality in patients with chronic kidney disease. The size of each square is proportional to the variability of the study estimate. Ellipses indicate not reported. n represents the number of patients who died and N represents the total number of patients in the cohort. aAbdominal aneurysm repair cohort. bLower extremity surgery cohort. cDerivation cohort. dValidation cohort. †Study included dialysis patients but did not quantify the number. ‡Study did not report whether dialysis patients were included. Kidney International 2008 73, 1069-1081DOI: (10.1038/ki.2008.29) Copyright © 2008 International Society of Nephrology Terms and Conditions
Figure 3 Adjusted risk of postoperative mortality in patients with chronic kidney disease. The size of each square is proportional to the variability of the study estimate. aLower extremity surgery cohort. bAbdominal aneurysm repair cohort. cDerivation cohort. dValidation cohort. Kidney International 2008 73, 1069-1081DOI: (10.1038/ki.2008.29) Copyright © 2008 International Society of Nephrology Terms and Conditions
Figure 4 GFR and postoperative mortality. The area of each circle is proportional to the number of patients in GFR strata for each study. Best fit lines with 95% CIs are from meta-regression (see the Materials and Methods section). Kidney International 2008 73, 1069-1081DOI: (10.1038/ki.2008.29) Copyright © 2008 International Society of Nephrology Terms and Conditions
Figure 5 Risk of postoperative cardiovascular events in patients with chronic kidney disease. Cardiovascular sequelae defined as any one or composite of arrhythmia, CHF, angina, cardiac arrest, pulmonary edema. The size of each square is proportional to the variability of the study estimate. Ellipses indicate not reported. n represents the number of patients who died and N represents the total number of patients in the cohort. aDerivation cohort. bValidation cohort. ‡Study did not report whether dialysis patients were included. Kidney International 2008 73, 1069-1081DOI: (10.1038/ki.2008.29) Copyright © 2008 International Society of Nephrology Terms and Conditions
Figure 6 Adjusted risk of cardiovascular sequelae in patients with chronic kidney disease. The size of each square is proportional to the variability of the study estimate. aDerivation cohort. bValidation cohort. Kidney International 2008 73, 1069-1081DOI: (10.1038/ki.2008.29) Copyright © 2008 International Society of Nephrology Terms and Conditions
Figure 7 Postoperative risks in dialysis patients. (a) Risk of postoperative mortality in patients receiving dialysis. (b) Risk of postoperative cardiovascular sequelae in patients receiving dialysis. The size of each square is proportional to the variability of the study estimate. aLower extremity surgery cohort. n represents the number of patients who died and N represents the total number of patients in the cohort. Kidney International 2008 73, 1069-1081DOI: (10.1038/ki.2008.29) Copyright © 2008 International Society of Nephrology Terms and Conditions