Chemokines in the Biology of Lung Cancer

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Presentation transcript:

Chemokines in the Biology of Lung Cancer Douglas Arenberg, MD Journal of Thoracic Oncology Volume 1, Issue 4, Pages 287-288 (May 2006) DOI: 10.1016/S1556-0864(15)31582-3 Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 (A) Angiogenic CXC chemokines (bullet shaped) derived from both malignant cells and tumor-infiltrating stromal cells induce angiogenesis by binding to CXCR2 present on tumor endothelium. (B) Stromal cell-derived factor 1 (now known as CXCL12) is constitutively produced in lymph nodes, liver, bone marrow, and the adrenal gland. This results in preferential “recruitment” to these organs of circulating tumor cells that express CXCR4. Journal of Thoracic Oncology 2006 1, 287-288DOI: (10.1016/S1556-0864(15)31582-3) Copyright © 2006 International Association for the Study of Lung Cancer Terms and Conditions