Volume 61, Issue 6, Pages (June 2002)

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Presentation transcript:

Volume 61, Issue 6, Pages 2240-2249 (June 2002) Relationships among inflammation nutrition and physiologic mechanisms establishing albumin levels in hemodialysis patients George A. Kaysen, Joel A. Dubin, Hans-Georg Müller, William E. Mitch, Laura M. Rosales, Nathan W. Levin, the HEMO Study Group Kidney International Volume 61, Issue 6, Pages 2240-2249 (June 2002) DOI: 10.1046/j.1523-1755.2002.00076.x Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 1 (A) Relationship between serum albumin concentration (g/dL), nPCR and C-reactive protein (CRP; after log transformation). Albumin = 3.785 -0.185*Log CRP)+(0.258*nPCR); r2 = 0.145; log CRP, P = 0.047, nPCR P = 0.04. The surface is a best fit model extrapolated using the method of least squares. The symbols represent values obtained from the individual patients. The vertical line descending from each symbol is to orient the symbol to the XY plane. (B) Relationship between serum albumin concentration, nPCR and α1 acid glycoprotein. The surface and symbols are as described in panel A. Albumin = 4.109 - (0.00205 ×α1 AG) + (0.229 × nPCR); r2 = 0.135; α1 acid glycoprotein, P = 0.026; nPCR, P = 0.023. Kidney International 2002 61, 2240-2249DOI: (10.1046/j.1523-1755.2002.00076.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 2 Relationship between albumin fractional catabolic rate (FCR) and α1 acid glycoprotein (α1 AG). FCR = 9.309 + (0.0209 ×α1 AG); P = 0.023. The regression is presented as the least squares fit (solid line) with 95% confidence levels (dashed lines). Kidney International 2002 61, 2240-2249DOI: (10.1046/j.1523-1755.2002.00076.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 3 Relationship between albumin FCR and ceruloplasmin. FCR = 8.058 + (0.0949 × ceruloplasmin); P = 0.013. The regression is presented as the least squares fit (solid line) with 95% confidence levels (dashed lines). Kidney International 2002 61, 2240-2249DOI: (10.1046/j.1523-1755.2002.00076.x) Copyright © 2002 International Society of Nephrology Terms and Conditions

Figure 4 (A) Relationship between albumin synthesis in g/1.73m2/day, plasma volume in percent body weight (PV%) at the time of the initial injection of [125I] albumin and normalized protein catabolic rate in g/kg (nPCR). The surface is a best fit model extrapolated using the method of least squares. The symbols represent values obtained from the individual patients. The vertical line descending from each symbol is to orient the symbol to the XY plane. Synthesis/1.73m2/day = 7.292 + (0.867*PV(%)+(3.444*nPCR); r2 = 0.259; PV %, P = 0.005; nPCR, P = 0.007. (B) Relationship between albumin synthesis in g/1.73m2/day, plasma volume in percent body weight (PV%) at the time of the initial injection of [125I] albumin and body mass index (BMI). Synthesis/1.73m2 = 2.812 +[1.803*PV(%)]+(0.380*BMI); r2 = 0.328*BMI; PV, P < 0.001; BMI, P < 0.001. Kidney International 2002 61, 2240-2249DOI: (10.1046/j.1523-1755.2002.00076.x) Copyright © 2002 International Society of Nephrology Terms and Conditions