2010 Update from the IACUC
Change in Committee Composition Effective July 1, 2010 Jeff Henegar, Ph.D. – Chair Pathology Phone: new member 4 members rotated off
New/Updated Policies Guidelines for submission and review of protocols to the IACUC Approved 1/19/10 Guidelines for submission and review of protocols to the IACUC Quarantine Procedures for Rodents from Non- Commercial Sources Approved 12/17/09 Quarantine Procedures for Rodents from Non- Commercial Sources Management of Supected Protocol Noncompliance - now includes list of Animal Research Related Issues of Noncompliance Management of Supected Protocol Noncompliance
Change in Policy One time 10% increase granted by chair now applies only to mice and rats All other species requires full committee review Required by OLAW in our Animal Welfare Assurance
Animal Activity Protocol Form Updated 10/2009 Effective 1/2010 – Investigators are required to submit protocols on updated form The format of the Assurance/Search/Narrative section has been changed to assist investigators in providing the necessary information required by the USDA and OLAW regulations. The Roland Medical Library reference desk (ext ) is available to provide additional assistance with protocol searches, if needed.
Assurance/Search/Narrative Search should address alternatives to potentially painful and/or distressful procedures Search of 2 databases required Narrative should address 3 Rs: refinement, reduction, replacement
Center for Biostatistics Option available for assistance with minimizing animal numbers necessary for obtaining valid results Interested investigators are encouraged to contact the Center's director Michael Griswold at to set up an initial meeting. Statistics/UMC_Biostatistics-summary.html Statistics/UMC_Biostatistics-summary.html
Protocol Compliance Please adhere to IACUC approved protocols It is necessary to modify the protocol as research plans evolve prior to initiating the activities
Pharmaceutical-grade Compounds Pharmaceutical-grade compounds should be used unless unavailable or scientifically justified and approved by the IACUC. NIH policy online at eutical_Compounds.pdf eutical_Compounds.pdf
Guide for Care and Use of Laboratory Animals 8 th edition Last update was in 1996 Additions to this eighth edition of the Guide include expanded coverage of the ethics of laboratory animal use; components of effective animal care and use Programs; and new guidelines for the housing, environment, and enrichment of terrestrial and aquatic animals, and for veterinary and clinical care. – National Academies Report
Environmental Enrichment The AWR (section 3.81) provide detailed information about enrichment plan specifically for nonhuman primates The Guide of the Care and Use of Laboratory Animals, 2010 offers a greatly expanded section on Environmental Enrichment dealing with all vertebrate species
Chemical Hazards The Office of Environmental Health and Safety has issued Standard Operating Procedures (SOPs) for handling of the following chemical hazards:Office of Environmental Health and Safety Vincristine Sulfate BrdU MPTP STZ LPS Paraquart Dichloride MS-222
Material Safety Data Sheets MSDS On-line Available on Intranet under Hot Spots
Post-operative/Post-procedural Monitoring Monitor and document recovery of animals If animal is not recovering, contact veterinary staff for assistance