Interaction of drug substrates and the AcrB-binding protomer analyzed with Autodock Vina docking software. Interaction of drug substrates and the AcrB-binding.

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Interaction of drug substrates and the AcrB-binding protomer analyzed with Autodock Vina docking software. Interaction of drug substrates and the AcrB-binding protomer analyzed with Autodock Vina docking software. Substrates are shown to bind to either the upper part (groove binder) (doxorubicin [A] and tetracycline [B]) or the lower part (cave binder) (chloramphenicol [C] and cyclohexane [D]) of the distal binding site. (Modified from reference 91.)‏ Xian-Zhi Li et al. Clin. Microbiol. Rev. 2015; doi:10.1128/CMR.00117-14