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Volume 16, Issue 6, Pages 1065-1068 (June 1996) PY in the Fly Receptor-like Tyrosine Phosphatases in Axonal Pathfinding Chi-Bin Chien Neuron Volume 16, Issue 6, Pages 1065-1068 (June 1996) DOI: 10.1016/S0896-6273(00)80131-2

Figure 1 The Five Drosophila RPTPs (A) Comparison of domain structure of Drosophila RPTPs, fasciclin II (fas II), and corkscrew; IgC2, FN III, SH2, and phosphatase domains are indicated. Asterisks: sequence data suggest that the second phosphatase domain of DPTP99A is inactive and that DPTP4E contains a second transmembrane domain. (B) Other properties of fly RPTPs. Closely related mammalian RPTPs, existence of multiple RNA splice forms, and protein expression pattern are listed for each RPTP, as well as the motor nerve branches affected in null mutants. Single dagger, the phenotype of dptp69D null mutants is greatly enhanced in dptp69D dptp99A double mutants. For references, see Desai et al., 1994, 1996; Krueger et al., 1996; Yang et al., 1991. Neuron 1996 16, 1065-1068DOI: (10.1016/S0896-6273(00)80131-2)

Figure 2 Loss of RPTPs Disrupts SNb Motor Axon Pathfinding (A) Left, inner view of a single segment of a filleted wild-type embryo, showing a subset of muscles (numbered), the five nerve branches (ISN, SNa–SNd; SNb shown thicker), and some of the terminals of SNb (closed circles). Muscle 30 is hidden; all nerve branches are shown though some actually pass behind muscles. Right, transverse section, showing the course of SNb (thick) compared with ISN (thin). (B) In Dlar mutants, SNb fails to enter its target region, but continues parallel to ISN. (C) dptp69D mutants show defasciculation defects, misrouting, stalling (diamonds), and aberrant terminations. (Breaks in nerves show alternate phenotypes.) dptp69D dptp99A double mutants have similar phenotypes to dptp69D, but with much greater penetrance. Orientation: d–v, dorsal–ventral; a–p, anterior–posterior; i–e, internal–external. Adapted from Desai et al., 1996; Krueger et al., 1996; Van Vactor et al., 1993. Neuron 1996 16, 1065-1068DOI: (10.1016/S0896-6273(00)80131-2)