Mouse models of pancreatic cancer

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Presentation transcript:

Mouse models of pancreatic cancer Steven D. Leach Cancer Cell Volume 5, Issue 1, Pages 7-11 (January 2004) DOI: 10.1016/S1535-6108(03)00337-4

Figure 1 Histology of normal and neoplastic pancreas A: Normal mouse pancreas demonstrating preponderant acinar cell mass, terminal intralobular ductal epithelium (black bracket), centroacinar cells (arrowheads), and endocrine islet (yellow bracket). Within this complex epithelial tissue, the location of dedicated epithelial precursor cells is unknown, and the cell of origin for pancreatic intraepithelial neoplasia is not yet defined. B: Human pancreatic intraepithelial neoplasia (PanIN), demonstrating columnar epithelium with papillary architecture and surrounding desmoplastic stroma. PanIN image courtesy of Dr. Ralph Hruban, Johns Hopkins University. Cancer Cell 2004 5, 7-11DOI: (10.1016/S1535-6108(03)00337-4)