Molecular Prophets of Death in the Fly

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Presentation transcript:

Molecular Prophets of Death in the Fly Antony Rodriguez, Po Chen, John M. Abrams The American Journal of Human Genetics Volume 62, Issue 3, Pages 514-519 (March 1998) DOI: 10.1086/301775 Copyright © 1998 The American Society of Human Genetics Terms and Conditions

Figure 1 Manipulation of tissue by engaging elements of the apoptotic machine. Selective expression of an apoptotic activator, grim, in the developing fly retina provokes massive cell death and deletion of this tissue. Compare wild-type eye (A) and ablated eye of the pGMRgrim strain (B). These deaths are completely prevented (C) by coexpression of p35, a viral antiapoptotic protein that inhibits caspase action. The result (C) demonstrates that preservation of apoptotic tissues may be achieved through targets of caspase function. (These panels are reprinted here from the article by Chen et al. [1996b, p. 1773], with the permission of Genes & Development and the Cold Spring Harbor Laboratory Press.) The American Journal of Human Genetics 1998 62, 514-519DOI: (10.1086/301775) Copyright © 1998 The American Society of Human Genetics Terms and Conditions

The American Journal of Human Genetics 1998 62, 514-519DOI: (10 Copyright © 1998 The American Society of Human Genetics Terms and Conditions