Volume 92, Issue 2, Pages (August 2017)

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Presentation transcript:

Volume 92, Issue 2, Pages 274-275 (August 2017) Journal club Kidney International Volume 92, Issue 2, Pages 274-275 (August 2017) DOI: 10.1016/j.kint.2017.06.002 Copyright © 2017 International Society of Nephrology Terms and Conditions

Figure 1 The figure shows (a) 55Fe uptake into divalent metal transporter 1–deficient (shDMT1) human intestinal Caco-2 cell line monolayers and (b) transepithelial transport (apical to basolateral) across same cell monolayers. It indicates that hinokitiol (500 nM), but not inactive C2-deoxy hinokitiol (C2deOHino), restores normal iron absorption (n = 3). shControl refers to Caco-2 monolayers that were transfected with a nontargeting control short hairpin RNA (shRNA) plasmid. From Grillo AS, SantaMaria AM, Kafina MD, et al. Restored iron transport by a small molecule promotes absorption and hemoglobinization in animals. Science. 2017;356:608–616. Reprinted with permission from AAAS. Kidney International 2017 92, 274-275DOI: (10.1016/j.kint.2017.06.002) Copyright © 2017 International Society of Nephrology Terms and Conditions

Figure 2 Shedding of PS-exposed plasma membrane bubbles during necroptosis. PS, phosphatidylserine. Reprinted from Cell, volume 169, Gong Y-N, Guy C, Olauson H, et al. ESCRT-III acts downstream of MLKL to regulate necroptotic cell death and its consequences, 286–300.e16, Copyright © 2017, with permission from Elsevier. Kidney International 2017 92, 274-275DOI: (10.1016/j.kint.2017.06.002) Copyright © 2017 International Society of Nephrology Terms and Conditions