Endothelial cells as vascular salt sensors

Slides:

Advertisements

Similar presentations

Plasma sodium and hypertension

Advertisements

Volume 82, Issue 1, Pages 7-8 (July 2012)

Dylan Burger, Adeera Levin Kidney International

Volume 83, Issue 3, Pages (March 2013)

Volume 79, Issue 6, Pages (March 2011)

Hyperuricemia induces endothelial dysfunction

Volume 79, Issue 9, Pages (May 2011)

Volume 83, Issue 2, Pages (February 2013)

Volume 85, Issue 4, Pages (April 2014)

Verotoxin biology: molecular events in vascular endothelial injury

Volume 85, Issue 3, Pages (March 2014)

Volume 77, Issue 1, Pages 5-6 (January 2010)

How to interpret the eGFR in patients with small body surface area

Methotrexate in the urine

Volume 76, Issue 3, Pages (August 2009)

Comorbidity and confounding in end-stage renal disease

Volume 74, Issue 3, Pages (August 2008)

Veerle P. Persy, Marc D. McKee Kidney International

Dominique A. Joly, Jean-Pierre Grünfeld Kidney International

Nephrology Crosswords: Hemodialysis

Volume 86, Issue 2, Pages (August 2014)

Volume 87, Issue 2, Pages (February 2015)

Blood pressure targets in hemodialysis patients

Frank Eitner, Jürgen Floege Kidney International

The promise of biomarkers for personalized renal cancer care

Volume 62, Issue 1, Pages (July 2002)

Volume 84, Issue 4, Pages (October 2013)

Structure, not just function

Volume 85, Issue 3, Pages (March 2014)

Disaster nephrology: crush injury and beyond

A physician's perseverance uncovers problems in a key nephrology study

Volume 83, Issue 5, Pages (May 2013)

Extracorporeal therapy in sepsis: are we there yet?

Volume 69, Issue 12, Pages (June 2006)

Volume 69, Issue 3, Pages (February 2006)

Volume 74, Issue 8, Pages (October 2008)

Volume 87, Issue 3, Pages (March 2015)

Nephrology Crossword: Peritoneal Dialysis

Calcium sensing in podocytes

Volume 87, Issue 1, Pages (January 2015)

Nephrology Crossword: Glomerulonephritis

Volume 92, Issue 4, (October 2017)

Juan Camilo Duque, Roberto I. Vazquez-Padron Kidney International

Volume 75, Issue 9, Pages (May 2009)

Insulin resistance and hypertension: new insights

Volume 81, Issue 4, Pages (February 2012)

Volume 81, Issue 8, Pages (April 2012)

Circadian regulation of renal function

A man with a hole in his penis

Cardiovascular risk assessment in kidney transplantation

Volume 82, Issue 9, Pages (November 2012)

Cardio-Kidney-Damage: a unifying concept

The vascular secret of Klotho

Volume 75, Issue 12, Pages (June 2009)

Volume 83, Issue 4, Pages (April 2013)

Volume 80, Issue 10, Pages (November 2011)

Is it the low-protein diet or simply the salt restriction?

Volume 70, Issue 3, Pages (August 2006)

Volume 71, Issue 9, Pages (May 2007)

Sundararaman Swaminathan, Matthew D. Griffin Kidney International

Volume 75, Issue 7, Pages (April 2009)

Aldosterone and potassium secretion by the cortical collecting duct

Volume 75, Issue 6, Pages (March 2009)

The international realities of live donor kidney transplantation

Microsomal prostaglandin E synthase-1 and blood pressure regulation

Volume 74, Issue 10, Pages (November 2008)

Volume 57, Issue 6, Pages (June 2000)

Quantitative estimation of renal blood flow by power Doppler ultrasonography in renovascular hypertensive dogs Tetsumasa Miyajima, Hiroshi Yokoyama,

The Ebf1 knockout mouse and glomerular maturation

Ronen Levi, Justin Silver Kidney International

Presentation transcript:

Endothelial cells as vascular salt sensors Hans Oberleithner, Kristina Kusche-Vihrog, Hermann Schillers Kidney International Volume 77, Issue 6, Pages 490-494 (March 2010) DOI: 10.1038/ki.2009.490 Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 1 Concept of how the mechanical stiffness of endothelial cells participates in the regulation of blood pressure. Kidney International 2010 77, 490-494DOI: (10.1038/ki.2009.490) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 2 Indentation technique using atomic force microscopy. Indentation curve with two different slopes. (modified from Oberleithner et al.15) Kidney International 2010 77, 490-494DOI: (10.1038/ki.2009.490) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 3 Relationship between cell stiffness and electrolyte concentrations. Please note that the electrolyte-induced changes in stiffness occur within minutes. Numbers close to the mean values (±s.e.m.) are the respective ion concentrations in the extracellular solution (mmol/l). (modified from Oberleithner et al.9,15) Kidney International 2010 77, 490-494DOI: (10.1038/ki.2009.490) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 4 Negative correlation between cell stiffness and nitric oxide (NO) release. NO release was derived from the nitrite concentrations measured in the supernatant culture media. Data were taken from Oberleithner et al.9,15 Kidney International 2010 77, 490-494DOI: (10.1038/ki.2009.490) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 5 Hypothesis for how sodium and potassium control the fluidity of the cortical zone (‘cell shell’) in an endothelial cell. Kidney International 2010 77, 490-494DOI: (10.1038/ki.2009.490) Copyright © 2010 International Society of Nephrology Terms and Conditions

Figure 6 Concept of how sodium, potassium, and aldosterone contribute to the regulation of blood vessel tone. Kidney International 2010 77, 490-494DOI: (10.1038/ki.2009.490) Copyright © 2010 International Society of Nephrology Terms and Conditions