Multisite Phosphorylation and the Countdown to S Phase

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Multisite Phosphorylation and the Countdown to S Phase Raymond J. Deshaies, James E. Ferrell Cell Volume 107, Issue 7, Pages 819-822 (December 2001) DOI: 10.1016/S0092-8674(01)00620-1

Figure 1 Multisite Phosphorylation Enables Sic1 Degradation at the G1/S Transition in Budding Yeast See text for details. Cell 2001 107, 819-822DOI: (10.1016/S0092-8674(01)00620-1)

Figure 2 Multisite Phosphorylation and Switch-like Responses (A) Temporal thresholds. The red curve represents a calculated time course for Sic1 destruction, assuming that Sic1 destruction is triggered by six equally rate determining phosphorylations. The other curves show Sic1 destruction if it is triggered by one fast (blue) or slow (green) phosphorylation. (B) Steady-state thresholds. Sic1 concentration as a function of Cln-CDK activity if degradation is triggered by one (blue curve) or six (green curve) phosphorylations. Modeling was carried out with Mathematica 2.2.2. Cell 2001 107, 819-822DOI: (10.1016/S0092-8674(01)00620-1)

Figure 3 Induced Proximity and the Binding of Sic1 Phosphopeptides to Secondary Sites on Cdc4 See text for details. Cell 2001 107, 819-822DOI: (10.1016/S0092-8674(01)00620-1)