PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria

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PD-L2 Elbows out PD-L1 to Rescue T Cell Immunity to Malaria Peter D. Crompton, Susan K. Pierce  Immunity  Volume 45, Issue 2, Pages 231-233 (August 2016) DOI: 10.1016/j.immuni.2016.08.001 Copyright © 2016 Terms and Conditions

Figure 1 PD-L2 Can Enhance T Cell Activation in Plasmodium-Infected Mice During malaria infection in humans, higher PD-L2 expression on DCs correlates with lower parasitemia. In mice, PD-L2 enhances CD4+ T cell immunity to malaria by competing with PD-L1 to diminish PD-1-mediated inhibition of T cell activation. Immunity 2016 45, 231-233DOI: (10.1016/j.immuni.2016.08.001) Copyright © 2016 Terms and Conditions

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