Doxycycline in patients with abdominal aortic aneurysms and in mice: Comparison of serum levels and effect on aneurysm growth in mice Amy K. Prall, BSa,

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Presentation transcript:

Doxycycline in patients with abdominal aortic aneurysms and in mice: Comparison of serum levels and effect on aneurysm growth in mice Amy K. Prall, BSa, G.Matthew Longo, MDa, William G. Mayhan, PhDb, Eugene A. Waltke, MDc, Beverly Fleckten, BS, CCRCa, Robert W. Thompson, MDd, B.Timothy Baxter, MDa,c Journal of Vascular Surgery Volume 35, Issue 5, Pages 923-929 (May 2002) DOI: 10.1067/mva.2002.123757 Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 1 Serum doxycycline concentration measurements in mice with three different oral doses of doxycycline and in control group shown in comparison with plasma doxycycline measurements in patients with AAAs. Journal of Vascular Surgery 2002 35, 923-929DOI: (10.1067/mva.2002.123757) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 2 Effects of different doses of oral doxycycline on aneurysm inhibition in murine model (aortic diameter on left axis) and relationship to serum doxycycline levels (right axis). Treatment groups of 50 mg/kg and 100 mg/kg showed statistically significant attenuation in aortic growth when compared with control group (0 mg/kg). *P <.05. Journal of Vascular Surgery 2002 35, 923-929DOI: (10.1067/mva.2002.123757) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 3 Zymogram shows expression of latent and active forms of MMP-2 and MMP-9 with increasing doses of doxycycline. Journal of Vascular Surgery 2002 35, 923-929DOI: (10.1067/mva.2002.123757) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 4 Impact of inhibiting aneurysm expansion by 30%, 40%, and 50% is shown. This figure is on the basis of an expansion rate of 10%/year. Journal of Vascular Surgery 2002 35, 923-929DOI: (10.1067/mva.2002.123757) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions