Prevalence of Antibodies Against Virus-Like Particles of Epidermodysplasia Verruciformis-Associated HPV8 in Patients at Risk of Skin Cancer Sabine Stark,

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Presentation transcript:

Prevalence of Antibodies Against Virus-Like Particles of Epidermodysplasia Verruciformis-Associated HPV8 in Patients at Risk of Skin Cancer Sabine Stark, Athanasios K. Petridis, Pawel G. Fuchs Journal of Investigative Dermatology Volume 111, Issue 4, Pages 696-701 (October 1998) DOI: 10.1046/j.1523-1747.1998.00360.x Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Analysis of HPV8-LI VLP. (A) Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of purified HPV8 L1 VLP. M, molecular weight marker 10 kDa ladder; 1, Coomassie blue stained gel; 2, western blot with guinea pig anti-HPV8 L1 anti-serum. (B) Electron micrograph of negatively stained HPV8 L1 VLP. Scale bar: 100 nm. Journal of Investigative Dermatology 1998 111, 696-701DOI: (10.1046/j.1523-1747.1998.00360.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Distribution of frequency of sera from different groups reacting with HPV8 L1 VLP at different levels as measured by extinction at 405 nm. The cut-off of 0.304 is indicated by arrows. Journal of Investigative Dermatology 1998 111, 696-701DOI: (10.1046/j.1523-1747.1998.00360.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Correlation of serum ELISA IgG reactivity to HPV8 and HPV16 L1 VLP. Sera from (A) general population (n = 145); (B) psoralene/UVA-treated psoriasis patients (n = 42); (C) RTR (n = 125); (D) skin tumor patients (n = 79). The cut-off for the HPV8 VLP-ELISA (0.304) is indicated by vertical lines, and the cut-off for the HPV16 VLP-ELISA (0.348) by horizontal lines. Journal of Investigative Dermatology 1998 111, 696-701DOI: (10.1046/j.1523-1747.1998.00360.x) Copyright © 1998 The Society for Investigative Dermatology, Inc Terms and Conditions