Epicutaneous immunotherapy for peanut allergy modifies IgG4 responses to major peanut allergens Stef J. Koppelman, PhD, Aurélie Peillon, MSc, Wenceslas.

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Presentation transcript:

Epicutaneous immunotherapy for peanut allergy modifies IgG4 responses to major peanut allergens Stef J. Koppelman, PhD, Aurélie Peillon, MSc, Wenceslas Agbotounou, PhD, Hugh A. Sampson, MD, Laurent Martin, PharmD Journal of Allergy and Clinical Immunology Volume 143, Issue 3, Pages 1218-1221.e4 (March 2019) DOI: 10.1016/j.jaci.2018.10.025 Copyright © 2018 The Authors Terms and Conditions

Fig 1 Correlation of IgE to Ara h 2 and IgE to Ara h 6. IgE levels to both Ara h 2 and IgE to Ara h 6 were determined with ISAC. ISU, ISAC Standardized Units. Journal of Allergy and Clinical Immunology 2019 143, 1218-1221.e4DOI: (10.1016/j.jaci.2018.10.025) Copyright © 2018 The Authors Terms and Conditions

Fig 2 Induction of IgG4 to individual peanut components by EPIT with 250-μg patch. A, Data obtained with ImmunoCAP. B, Data obtained with ISAC. Numbers on x-axis represent months of EPIT (0 is baseline). Where less than 25 markers per time point are plotted, the markers at less than 0.05 ISU for ISAC and less than 0.07 mgA/L for ImmunoCAP represent multiple markers up to a total of 25. Bars show medians. ISU, ISAC Standardized Units. Open circles, baseline; filled triangles, 3 months; open squares, 6 months; filled circles, 12 months. Journal of Allergy and Clinical Immunology 2019 143, 1218-1221.e4DOI: (10.1016/j.jaci.2018.10.025) Copyright © 2018 The Authors Terms and Conditions

Fig E1 Correlation of ISAC with ImmunoCAP. A, Correlation between the sum of IgE titers to peanut components determined by ImmunoCAP and ISAC (sum ISAC excluding Ara h 6: black circles; sum ISAC including Ara h 6: open circles). B, Correlation between IgE to total peanut in ImmunoCAP (ImmunoCAP F13) and the sum of IgE to peanut components measured by ImmunoCAP (black squares) and ISAC (open circles). C, Correlation of IgE titers to individual peanut components determined by ImmunoCAP and ISAC (Ara h 1: black diamonds; Ara h 2: open squares; Ara h3: gray triangles; Ara h 8: crosses; Ara h 9: black squares). D, Correlation of IgG4 titers to individual peanut components determined by ImmunoCAP and ISAC (same marker assignment as for Fig E1, C). Journal of Allergy and Clinical Immunology 2019 143, 1218-1221.e4DOI: (10.1016/j.jaci.2018.10.025) Copyright © 2018 The Authors Terms and Conditions

Fig E2 Evolution of IgE to individual peanut components by EPIT with 250-μg patch. Data obtained with ImmunoCAP. Numbers on the x-axis represent months of EPIT (0 is baseline). Where less than 25 markers per time point are plotted, the markers at less than 0.07 represent multiple markers up to a total of 25. Bars show medians. Open circles: baseline; filled triangles: 3 months; open squares: 6 months; filled circles: 12 months. Journal of Allergy and Clinical Immunology 2019 143, 1218-1221.e4DOI: (10.1016/j.jaci.2018.10.025) Copyright © 2018 The Authors Terms and Conditions