Chapter 9 Mutation and Repair 24 September, 2004.

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Presentation transcript:

Chapter 9 Mutation and Repair 24 September, 2004

Overview DNA is replicated with high fidelity, but errors do occur. Errors during replication may be misincorporation or slippage. Errors that are not repaired by proofreading may be repaired my the mismatch repair systems. Mismatch repair systems rely on methylation to determine which base is correct. In addition to replication errors, DNA can be damaged by radiation, chemicals, or spontaneous reactions. DNA repair systems are specialized according to the type of damage they address.

Transitions and Transversions

Ratification of unrepaired errors

Mismatch Repair

Dam Methylation in E. coli

Exonuclease activity exposes lesion

DNA Damage

Base Analogs and Intercalators

Photoreactivation

O6-Me-G repair

Base excision repair

Base excision repair

Fail-safe systems

Excision Repair

Excision repair may be coupled to transcription.

Translesion Synthesis

Ames Test

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