How Effective Is Tacrolimus in the Imiquimod-Induced Mouse Model of Psoriasis? Hannah Pischon, Moritz Radbruch, Anja Ostrowski, Fabian Schumacher, Stefan.

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Presentation transcript:

How Effective Is Tacrolimus in the Imiquimod-Induced Mouse Model of Psoriasis? Hannah Pischon, Moritz Radbruch, Anja Ostrowski, Fabian Schumacher, Stefan Hönzke, Burkhard Kleuser, Sarah Hedtrich, Joachim W. Fluhr, Achim D. Gruber, Lars Mundhenk Journal of Investigative Dermatology Volume 138, Issue 2, Pages 455-458 (February 2018) DOI: 10.1016/j.jid.2017.09.019 Copyright © 2017 The Authors Terms and Conditions

Figure 1 Clinical and histological data of treated psoriasis-like dermatitis using different protocols. (a–c) Treatment protocol schemes: data obtained using (a) the first protocol: treated daily starting on day 3 after induction of inflammation; (b) the second protocol: daily treatment started on same day 0 as induction of inflammation, or (c) the third protocol: treatment twice daily from day 0; (d–f) ear thickness, (g–i) transepidermal water loss (TEWL), (j–l) increase in epidermal CD3-positive cells; mean ± standard deviation; t-test Holm-Sidak-corrected; P < 0.05: * compared with the untreated IMQ model control group, # compared with the control cream- or vehicle ointment-treated control group, for histological parameters additionally (j–l): § compared with the healthy control group; additional parameters (erythema, skin hydration, PASI score, epidermal thickness), and macroscopic and histologic skin phenotype images are shown in Supplementary Figure S2. DXM, dexamethasone; HPF, high power field (400x); IMQ, imiquimod; PASI, modified psoriasis area and severity index; TAC, tacrolimus. Journal of Investigative Dermatology 2018 138, 455-458DOI: (10.1016/j.jid.2017.09.019) Copyright © 2017 The Authors Terms and Conditions

Figure 2 Tacrolimus content in different skin layers determined by LC-MS/MS. Tacrolimus content per area of skin from separated skin layers by tape stripping (stratum corneum) and subsequent heat separation of remaining viable epidermis and dermis; data were obtained from mice treated according the second treatment protocol; mean ± standard deviation. LC-MS/MS, liquid chromatography tandem-mass spectrometry. Journal of Investigative Dermatology 2018 138, 455-458DOI: (10.1016/j.jid.2017.09.019) Copyright © 2017 The Authors Terms and Conditions