Recombinant human insulin-like growth factor-1 induces an anabolic response in malnourished CAPD patients  Denis Fouque, Susy C. Peng, Eshan Shamir, Joel.

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Recombinant human insulin-like growth factor-1 induces an anabolic response in malnourished CAPD patients  Denis Fouque, Susy C. Peng, Eshan Shamir, Joel D. Kopple  Kidney International  Volume 57, Issue 2, Pages 646-654 (October 2000) DOI: 10.1046/j.1523-1755.2000.00886.x Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 1 Daily nitrogen balance (histograms) values on the left vertical axis, obtained in three of the six patients. The close circles (right vertical axis) represent the serum urea nitrogen (SUN) profile as measured every five days in all patients (statistic shown in the text, Table 2, and Table 5). Recombinant insulin-like growth factor-1 (rhIGF-1) treatment was commenced on day 16. After that, blood was drawn for serum urea nitrogen (SUN) determination. Day 16 nitrogen balance was calculated after that each patient received the two first rhIGF-1 injections. Kidney International 2000 57, 646-654DOI: (10.1046/j.1523-1755.2000.00886.x) Copyright © 2000 International Society of Nephrology Terms and Conditions

Figure 2 Serum insulin-like growth factor-1 (IGF-1) profile in six patients receiving rhIGF-1 subcutaneous injections every 12 hours, starting on day 16, after the morning blood draw. Note that during the treatment phase, the serum IGF-1 level was measured 12 hours after the previous injection and just before the morning rhIGF-1 administration. The asterisk indicates an overall increase from baseline (P < 0.0001, ANOVA). Kidney International 2000 57, 646-654DOI: (10.1046/j.1523-1755.2000.00886.x) Copyright © 2000 International Society of Nephrology Terms and Conditions