Genome-wide association study of the age of onset of childhood asthma

Slides:

Advertisements

Similar presentations

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients Xingnan Li, PhD, MS, Gregory A. Hawkins,

Advertisements

Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans Rachel A. Myers, PhD, Blanca E. Himes,

Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications Judie A. Howrylak, MD, Anne L.

The natural history of soy allergy

Theresa W. Guilbert, MD, David T. Mauger, PhD, David B

Blanca E. Himes, Gary M. Hunninghake, James W. Baurley, Nicholas M

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients Xingnan Li, PhD, MS, Gregory A. Hawkins,

Vitamin D Insufficiency and Asthma in a US Nationwide Study

Santa Jeremy Ono, BA, PhD, Mark B. Abelson, MD

Ann-Marie M. Schoos, MD, PhD, Jacob D

Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications Judie A. Howrylak, MD, Anne L.

Sunita Sharma, MD, MPH, Xiaobo Zhou, PhD, Derek M

Genome-wide association study of lung function phenotypes in a founder population Tsung-Chieh Yao, MD, PhD, Gaixin Du, MS, Lide Han, PhD, Ying Sun, MS,

No evidence of large genetic effects on steroid response in asthma patients Michael Mosteller, PhD, Louise Hosking, BSc, Kay Murphy, PhD, Judong Shen,

Markus J. Ege, MD, David P. Strachan, MD, William O. C. M

Decreased response to inhaled steroids in overweight and obese asthmatic children Erick Forno, MD, MPH, Rachel Lescher, MD, Robert Strunk, MD, Scott Weiss,

Serum vitamin D levels and severe asthma exacerbations in the Childhood Asthma Management Program study John M. Brehm, MD, MPH, Brooke Schuemann, BS,

A genome-wide association study to identify genetic determinants of atopy in subjects from the United Kingdom Yize I. Wan, BMedSci, David P. Strachan,

Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans Rachel A. Myers, PhD, Blanca E. Himes,

Probiotics during the first 7 years of life: A cumulative risk reduction of eczema in a randomized, placebo-controlled trial Marko Kalliomäki, MD, PhD,

Genome-wide interaction study of gene-by-occupational exposure and effects on FEV1 levels Kim de Jong, PhD, Judith M. Vonk, PhD, Wim Timens, PhD, Yohan.

Albert M. Levin, PhD, Rasika A

Prematurity, atopy, and childhood asthma in Puerto Ricans

S. Melkorka Maggadottir, MD, Jin Li, PhD, Joseph T

The Childhood Asthma Control Test∗: Retrospective determination and clinical validation of a cut point to identify children with very poorly controlled.

Genetic risk factors for decreased bone mineral accretion in children with asthma receiving multiple oral corticosteroid bursts Heung-Woo Park, MD, PhD,

Factors influencing the infant gut microbiome at age 3-6 months: Findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART)

Corticosteroid use and bone mineral accretion in children with asthma: Effect modification by vitamin D Sze Man Tse, MDCM, H. William Kelly, PharmD,

Peter M. Wolfgram, MD, David B. Allen, MD

CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies Michael J. McGeachie, PhD, Ann.

Theresa W. Guilbert, MD, David T. Mauger, PhD, David B

Classification of childhood asthma phenotypes and long-term clinical responses to inhaled anti-inflammatory medications Judie A. Howrylak, MD, Anne L.

An age-dependent association of mannose-binding lectin-2 genetic variants on HIV-1– related disease in children Kumud K. Singh, PhD, Alexis Lieser, MD,

Xingnan Li, PhD, Timothy D. Howard, PhD, Siqun L

Maternal microchimerism protects against the development of asthma

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects Dara.

Polymorphisms of chitinases are not associated with asthma

Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3)

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

H. William Kelly, PharmD Journal of Allergy and Clinical Immunology

Autophagy: Nobel Prize 2016 and allergy and asthma research

Andrew T. DeWan, PhD, Elizabeth W

Development and cross-sectional validation of the Childhood Asthma Control Test Andrew H. Liu, MD, Robert Zeiger, MD, Christine Sorkness, PharmD, Todd.

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Mark Granada, MD, Jemma B. Wilk, DSc, Marina Tuzova, MD, PhD, David P

African ancestry and lung function in Puerto Rican children

Erick Forno, MD, MPH, Edna Acosta-Pérez, PhD, MSc, John M

Inhaled corticosteroid treatment modulates ZNF432 gene variant’s effect on bronchodilator response in asthmatics Ann Chen Wu, MD, MPH, Blanca E. Himes,

Geographic variability in childhood asthma prevalence in Chicago

A single intervention for cockroach control reduces cockroach exposure and asthma morbidity in children Felicia A. Rabito, PhD, MPH, John C. Carlson,

Erick Forno, MD, MPH, Yueh-Ying Han, PhD, Radhika H

Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations Gary M. Hunninghake, MD, MPH, Manuel E. Soto-Quirós,

Genome-wide expression profiles identify potential targets for gene-environment interactions in asthma severity Joanne E. Sordillo, ScD, MS, Roxanne.

Genome-wide interaction study of dust mite allergen on lung function in children with asthma Erick Forno, MD, MPH, Joanne Sordillo, MD, MPH, John Brehm,

Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases Xingnan Li, PhD, Elizabeth J. Ampleford,

Genetic predictors associated with improvement of asthma symptoms in response to inhaled corticosteroids Heung-Woo Park, MD, PhD, Amber Dahlin, PhD,

Genome-wide association study reveals class I MHC–restricted T cell–associated molecule gene (CRTAM) variants interact with vitamin D levels to affect.

Atopic endotype in childhood

No evidence of large genetic effects on steroid response in asthma patients Michael Mosteller, PhD, Louise Hosking, BSc, Kay Murphy, PhD, Judong Shen,

Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challenge Vernon M. Chinchilli, PhD, Laura Fisher, MD, Timothy.

Asthma: The past, future, environment, and costs

The natural history of milk allergy in an observational cohort

Personal and parental nativity as risk factors for food sensitization

KIF3A genetic variation is associated with pediatric asthma in the presence of eczema independent of allergic rhinitis Elisabet Johansson, PhD, Jocelyn.

Theresa W. Guilbert, MD, David T. Mauger, PhD, David B

Asthma Control Test: Reliability, validity, and responsiveness in patients not previously followed by asthma specialists Michael Schatz, MD, MS, Christine.

Environmental factors and eosinophilic esophagitis

Paradoxical psoriasis following anti–TNF therapy in ankylosing spondylitis: A population- based cohort study Jung Min Bae, MD, PhD, Hyuck Sun Kwon, MD,

Natural history of cow’s milk allergy

Presentation transcript:

Genome-wide association study of the age of onset of childhood asthma Erick Forno, MD, MPH, Jessica Lasky-Su, ScD, Blanca Himes, PhD, Judie Howrylak, MD, Clare Ramsey, MD, MPH, John Brehm, MD, MPH, Barbara Klanderman, PhD, John Ziniti, BA, Erik Melén, MD, PhD, Goran Pershagen, MD, PhD, Magnus Wickman, MD, PhD, Fernando Martinez, MD, Dave Mauger, PhD, Christine Sorkness, PharmD, Kelan Tantisira, MD, Benjamin A. Raby, MD, MPH, Scott T. Weiss, MD, MS, Juan C. Celedón, MD, DrPH Journal of Allergy and Clinical Immunology Volume 130, Issue 1, Pages 83-90.e4 (July 2012) DOI: 10.1016/j.jaci.2012.03.020 Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Plots for CAMP GWAS. Manhattan plot shows the −log10 P value by the chromosomal position for the GWAS with age of onset as the phenotype in the population-based adjusted survival analysis in CAMP. Red line, Threshold for a P value of less than .05 after Bonferroni correction (P < 9.8 × 10−8). Blue line, Threshold for a P value of less than .10 after Bonferroni correction (P < 2.0 × 10−7). Chr, Chromosome. Journal of Allergy and Clinical Immunology 2012 130, 83-90.e4DOI: (10.1016/j.jaci.2012.03.020) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Kaplan-Meier curves for age of onset of asthma in CAMP by genotype of replicated SNPs. Time to onset of asthma in CAMP for rs9815663 (A), rs7927044 (B), and rs4658627 (C) is shown. Blue dashed line, 0 risk alleles; red continuous line, 1 to 2 copies of risk allele. Journal of Allergy and Clinical Immunology 2012 130, 83-90.e4DOI: (10.1016/j.jaci.2012.03.020) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Age of onset and asthma phenotypes by the presence of any the 2 earlier-onset SNPs (rs9815663 and rs7927044). A, Time to onset of asthma in CAMP. Blue dashed line, Children with none of the earlier-onset SNPs; Red continuous line, children with 1 or more of the SNPs. B, FEV1 during 4 years of follow-up in CAMP. C, Albuterol use score during 4 years of follow-up in CAMP. Journal of Allergy and Clinical Immunology 2012 130, 83-90.e4DOI: (10.1016/j.jaci.2012.03.020) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 LD plot from CAMP for SNP rs9815663 and −log10 P values for associated SNPs. LD plot for SNP rs9815663 (±30 kb) is shown (bottom) with −log10 P values for association with age of onset of asthma in CAMP (top). Red, rs9815663; orange, 10 SNPs in high LD (r2 > 0.75); green, 3 SNPs in moderate LD (r2 > 0.50). Journal of Allergy and Clinical Immunology 2012 130, 83-90.e4DOI: (10.1016/j.jaci.2012.03.020) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Probability quantile-quantile (QQ) plot for the CAMP GWAS. Journal of Allergy and Clinical Immunology 2012 130, 83-90.e4DOI: (10.1016/j.jaci.2012.03.020) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 LD plots for SNPs rs9815663 (A), rs7927044 (B), and rs4658627 (C). Figures show the LD plots for the 3 top SNPs from the CAMP GWAS. Plots were obtained by using imputed genotypic data in CAMP generated from the 1000 Genomes Project. Journal of Allergy and Clinical Immunology 2012 130, 83-90.e4DOI: (10.1016/j.jaci.2012.03.020) Copyright © 2012 American Academy of Allergy, Asthma & Immunology Terms and Conditions