Interaction of Donor and Recipient Age: Do Older Heart Transplant Recipients Require Younger Hearts? Malini Daniel, MD, Carol Chen, MD, Jennifer Chung,

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Interaction of Donor and Recipient Age: Do Older Heart Transplant Recipients Require Younger Hearts? Malini Daniel, MD, Carol Chen, MD, Jennifer Chung, MD, Lee Goldberg, MD, Michael A. Acker, MD, Pavan Atluri, MD The Annals of Thoracic Surgery Volume 107, Issue 1, Pages 62-66 (January 2019) DOI: 10.1016/j.athoracsur.2018.06.085 Copyright © 2019 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 LOESS regression comparing donor age in years to 10-year all-cause mortality for transplant recipients more than age 60 years. The LOESS is a local regression analysis of nonparametric data to smooth datapoints and define local relationships. Blue symbols indicate LOESS scatterplot model; red line indicates predicted univariate regression; shading represents 95% confidence interval. The estimated inflection point in donor age above which advanced aged recipients (age more than 60 years) incurred increased risk is identified by the red arrow. (CI = confidence interval.) The Annals of Thoracic Surgery 2019 107, 62-66DOI: (10.1016/j.athoracsur.2018.06.085) Copyright © 2019 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Kaplan-Meier 5-year survival curves for recipients aged 60 years and more stratified by use of younger age donor (less than 50 years [solid line]) compared with advanced age donor (50 years or more [broken line]). Five-year survival was significantly lower among recipients who received an advanced age heart compared with those receiving a younger heart (67% versus 73%, respectively; log rank p < 0.001). The Annals of Thoracic Surgery 2019 107, 62-66DOI: (10.1016/j.athoracsur.2018.06.085) Copyright © 2019 The Society of Thoracic Surgeons Terms and Conditions