Effects of thoracic epidural anaesthesia on microvascular gastric mucosal oxygenation in physiological and compromised circulatory conditions in dogs†

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Effects of thoracic epidural anaesthesia on microvascular gastric mucosal oxygenation in physiological and compromised circulatory conditions in dogs† Schwarte L.A. , Picker O. , Höhne C. , Fournell A. , Scheeren T.W.L. British Journal of Anaesthesia Volume 93, Issue 4, Pages 552-559 (October 2004) DOI: 10.1093/bja/aeh235 Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 1 Experimental protocol. BL=baseline; PEEP=positive end-expiratory pressure; EPI=epidural drug infusion; FL=fluid resuscitation; POST=post-PEEP period. British Journal of Anaesthesia 2004 93, 552-559DOI: (10.1093/bja/aeh235) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 2 Effects of TEA and epidural saline infusion (controls) on gastric mucosal microvascular haemoglobin oxygenation (μHbO2), systemic oxygen-transport (DO2), and MAP under physiological conditions. Data presented as absolute values, n=6 dogs per group, mean (sem), *P<0.05. TEA maintained μHbO2, despite significantly decreasing DO2 and MAP. British Journal of Anaesthesia 2004 93, 552-559DOI: (10.1093/bja/aeh235) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 3 Effect of TEA and epidural saline infusion (controls) on gastric mucosal microvascular haemoglobin oxygenation (μHbO2), systemic oxygen-transport (DO2), and MAP under compromised cardiocirculatory conditions, before and after fluid resuscitation. Data presented as absolute values, n=6 dogs per group, mean (sem), *P<0.05. TEA aggravated the PEEP-induced decrease of μHbO2 and DO2, compared with controls, whereas fluid resuscitation restored μHbO2 and DO2. British Journal of Anaesthesia 2004 93, 552-559DOI: (10.1093/bja/aeh235) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 4 Effects of TEA (solid line, r2=0.77) and epidural saline infusion (controls, dashed line, r2=0.90) on the relationship between systemic oxygen-transport (DO2) and regional mucosal oxygenation (μHbO2). Data are absolute values (mean (sem)) from n=6 dogs per group. British Journal of Anaesthesia 2004 93, 552-559DOI: (10.1093/bja/aeh235) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions