Gene therapy with adenovirus-mediated myocardial transfer of vascular endothelial growth factor 121 improves cardiac performance in a pacing model of.

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Gene therapy with adenovirus-mediated myocardial transfer of vascular endothelial growth factor 121 improves cardiac performance in a pacing model of congestive heart failure Eros Leotta, MDa, Gerald Patejunas, PhDa, Glenn Murphy, MDa, Joseph Szokol, MDa, Leslie McGregor, BSa, JoAnn Carbray, BSa, Adam Hamawy, MDb, David Winchester, MDa, Neil Hackett, PhDb, Ronald Crystal, MDb, Todd Rosengart, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 123, Issue 6, Pages 1101-1113 (June 2002) DOI: 10.1067/mtc.2002.121044 Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Schematic of ventricular sectioning in the short axis at the midventricular (midpapillary) level for echocardiographic analysis of FWT. The Journal of Thoracic and Cardiovascular Surgery 2002 123, 1101-1113DOI: (10.1067/mtc.2002.121044) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Echocardiographic assessment of the percentage of FAC of the left ventricular cavity (systole vs diastole) in the short axis at the midventricular (midpapillary) level calculated as described in the “Methods” section (mean ± SD). S, Initial operation; BP, before pacing; 0, 7, 14, and 21, days after cessation of pacing. Statistical comparisons between AdCUVEGF121.1 and AdNull groups are provided above the corresponding time point. Statistically significant comparisons for AdNull at various time points and at baseline (BP) are provided as indicated (*P <.05, **P <.01). The Journal of Thoracic and Cardiovascular Surgery 2002 123, 1101-1113DOI: (10.1067/mtc.2002.121044) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Echocardiographic assessment of the percentage of FAC of the left ventricular cavity (systole vs diastole) in the short axis at the midventricular (midpapillary) level calculated as the percentage of change (mean ± SD) of each animal from its corresponding prepacing baseline value, as described in the “Methods” section. BP, Before pacing; 0, 7, 14, and 21, days after cessation of pacing. Statistical comparisons between the AdCUVEGF121.1 and AdNull groups are provided above the corresponding time point. Statistically significant comparisons for AdNull at various time points and at baseline (BP) are provided as indicated (*P <.05, **P <.01). The Journal of Thoracic and Cardiovascular Surgery 2002 123, 1101-1113DOI: (10.1067/mtc.2002.121044) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Sonomicrometric assessment of ventricular function. All analyses are based on measurements with piezoelectric crystals of short- and long-axis dimensions in systole versus diastole calculated as described in the “Methods” section. Depicted are absolute values and percentage changes from the prepacing baseline value of each animal (mean ± SD), respectively, in short-axis segmental shortening (A and B), stroke volume (C and D), and cardiac output (E and F). S, Initial operation; BP, before pacing; 0, 7, 14, and 21, days after cessation of pacing. Values are AdCUVEGF121.1 (open circles) versus AdNull (filled circles). Statistical comparisons between AdCUVEGF121.1 and AdNull groups are provided above the corresponding time point. Statistically significant comparisons for AdNull at various time points and at baseline (BP) are provided as indicated (*P <.05, **P <.01). The Journal of Thoracic and Cardiovascular Surgery 2002 123, 1101-1113DOI: (10.1067/mtc.2002.121044) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 Sonomicrometry assessment of ventricular function after administration of epinephrine. All analyses are based on measurements from piezoelectric crystals measuring short- and long-axis dimensions in systole versus diastole calculated as described in the “Methods” section. Depicted are absolute values and percentage changes from the prepacing baseline value of each animal (mean ± SD), respectively, in short-axis segmental shortening (A and B), stroke volume (C and D), and cardiac output (E and F). S, Initial operation; BP, before pacing; 0, 7, 14, and 21, days after cessation of pacing. Values are AdCUVEGF121.1 (open circles) versus AdNull (filled circles). Statistical comparisons between AdCUVEGF121.1 and AdNull groups are provided above the corresponding time point. Statistically significant comparisons for AdNull at various time points and at baseline (BP) are provided as indicated (*P <.05, **P <.01). The Journal of Thoracic and Cardiovascular Surgery 2002 123, 1101-1113DOI: (10.1067/mtc.2002.121044) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions