Identification of serological biomarker profiles associated with total joint replacement in osteoarthritis patients R.H.G.P. Arends, M.A. Karsdal, K.M.

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Identification of serological biomarker profiles associated with total joint replacement in osteoarthritis patients R.H.G.P. Arends, M.A. Karsdal, K.M. Verburg, C.R. West, A.C. Bay-Jensen, D.S. Keller Osteoarthritis and Cartilage Volume 25, Issue 6, Pages 866-877 (June 2017) DOI: 10.1016/j.joca.2017.01.006 Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Baseline for patients with no NSAID use during screening and <90 days during treatment A) CART using a minimum split rule of 30 and B) corresponding ROC curve. Based on 2000 stratified bootstrap replicates with threshold set to 0.5, medians (95% CI) are: AUC = 0.8315 (0.7753–0.8876), P < 0.0001; specificity = 0.7727 (0.7078–0.8377); sensitivity = 0.7681 (0.6522–0.8551); arrow denotes the predicted median specificity and the predicted median sensitivity. Osteoarthritis and Cartilage 2017 25, 866-877DOI: (10.1016/j.joca.2017.01.006) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Baseline for patients with NSAID use during screening and <90 days during treatment A) CART using a minimum split rule of 30 and B) corresponding ROC curve. Based on 2000 stratified bootstrap replicates with threshold set to 0.5, medians (95% CI) are: AUC: 0.7654 (0.6881–0.8428), P < 0.000175; specificity = 0.5508 (0.4576–0.6356); sensitivity = 0.7917 (0.6667–0.8958); arrow denotes the predicted median specificity and the predicted median sensitivity. Osteoarthritis and Cartilage 2017 25, 866-877DOI: (10.1016/j.joca.2017.01.006) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Baseline for patients with NSAID use during screening and ≥90 days during treatment A) CART using a minimum split rule of 30 and B) corresponding ROC curve. Based on 2000 stratified bootstrap replicates with threshold set to 0.5, medians (95% CI) are: AUC = 0.7317 (0.667–0.7965), P < 0.0001; thresholds = 0.5; specificity: 0.7518 (0.6809 0.8227); sensitivity: 0.6374 (0.5385–0.7253); arrow denotes the predicted median specificity and the predicted median sensitivity. Osteoarthritis and Cartilage 2017 25, 866-877DOI: (10.1016/j.joca.2017.01.006) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Box plots for the biomarker PINP at baseline, antecedent and coincident for cases and controls. NSAID user = NSAID was used during screening and ≥90 days during treatment; nonNSAID user = no NSAID use during screening and <90 days of NSAID use during treatment; scrNSAID user = NSAID use during screening and <90 days during treatment. Osteoarthritis and Cartilage 2017 25, 866-877DOI: (10.1016/j.joca.2017.01.006) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Box plots for the biomarker ICTP at baseline, antecedent and coincident for cases and controls. Osteoarthritis and Cartilage 2017 25, 866-877DOI: (10.1016/j.joca.2017.01.006) Copyright © 2017 Osteoarthritis Research Society International Terms and Conditions