J.H. Levy, M. Gottge, F. Szlam, R. Zaffer, C. McCall

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Presentation transcript:

Weal and flare responses to intradermal rocuronium and cisatracurium in humans J.H. Levy, M. Gottge, F. Szlam, R. Zaffer, C. McCall British Journal of Anaesthesia Volume 85, Issue 6, Pages 844-849 (December 2000) DOI: 10.1093/bja/85.6.844 Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

Fig 1 Number of subjects with positive responses to increasing concentrations of rocuronium, cisatracurium and to positive and negative controls (n=30). *P<0.05 vs. saline control. British Journal of Anaesthesia 2000 85, 844-849DOI: (10.1093/bja/85.6.844) Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

Fig 2 Weal sizes (mean and se) after intradermal injection of normal saline, atracurium 10−4 M, histamine 10−4 M and increasing concentrations of rocuronium and cisatracurium. *P<0.05 vs. saline control. British Journal of Anaesthesia 2000 85, 844-849DOI: (10.1093/bja/85.6.844) Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

Fig 3 Flare sizes (mean and se) after intradermal injection of normal saline, atracurium 10−4 M, histamine 10−4 M and increasing concentrations of rocuronium and cisatracurium. *P<0.05 vs. saline control. British Journal of Anaesthesia 2000 85, 844-849DOI: (10.1093/bja/85.6.844) Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

Fig 4 (a) Electron micrograph of a human cutaneous mast cell from a rocuronium-induced wheal. The cell outline is well defined, and the electron-dense cytoplasmic granules that store mast cell mediators are well delineated (arrow), without any evidence of degranulation. Note the collagen bundles around the mast cell (arrow). (b) Electron micrograph of a human cutaneous mast cell from a cisatracurium-induced wheal. Most of the cytoplasmic granules are swollen, and demonstrate varying degrees of decreased density and loss of organization consistent with ongoing degranulation (arrow). Note the collagen bundles around the mast cell (arrow). British Journal of Anaesthesia 2000 85, 844-849DOI: (10.1093/bja/85.6.844) Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

Fig 4 (a) Electron micrograph of a human cutaneous mast cell from a rocuronium-induced wheal. The cell outline is well defined, and the electron-dense cytoplasmic granules that store mast cell mediators are well delineated (arrow), without any evidence of degranulation. Note the collagen bundles around the mast cell (arrow). (b) Electron micrograph of a human cutaneous mast cell from a cisatracurium-induced wheal. Most of the cytoplasmic granules are swollen, and demonstrate varying degrees of decreased density and loss of organization consistent with ongoing degranulation (arrow). Note the collagen bundles around the mast cell (arrow). British Journal of Anaesthesia 2000 85, 844-849DOI: (10.1093/bja/85.6.844) Copyright © 2000 British Journal of Anaesthesia Terms and Conditions