Reduced placental FOXP3 associated with subsequent infant allergic disease Susan L. Prescott, PhD, MD, Meri Tulic, PhD, Annette Osei-Kumah, PhD, Tara.

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Presentation transcript:

Reduced placental FOXP3 associated with subsequent infant allergic disease Susan L. Prescott, PhD, MD, Meri Tulic, PhD, Annette Osei-Kumah, PhD, Tara Richman, BSc, Maxine Crook, BSc, David Martino, BSc, Janet A. Dunstan, PhD, Boris Novakovic, PhD, Richard Saffery, PhD, Vicki L. Clifton, PhD Journal of Allergy and Clinical Immunology Volume 128, Issue 4, Pages 886-887.e5 (October 2011) DOI: 10.1016/j.jaci.2011.05.017 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Placental FOXP3 expression in infants with and without allergic disease. A, FOXP3 mRNA expression (normalized to housekeeping gene, β-actin) as means and 95% CIs for infants with allergy (solid bars) and those without allergy (open bars). B, Levels are also shown separately for male and female infants according to allergic status (∗P < .05). Journal of Allergy and Clinical Immunology 2011 128, 886-887.e5DOI: (10.1016/j.jaci.2011.05.017) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Comparison of FOXP3 gene methylation patterns in cord blood and placenta. Methylation of CpG sites in the FOXP3 promoter (A) and FOXP3 enhancer (B) for placental samples (n = 11) and matched cord blood samples (n = 11) as means and 95% CIs (∗P < .05; ∗∗P < .01). Journal of Allergy and Clinical Immunology 2011 128, 886-887.e5DOI: (10.1016/j.jaci.2011.05.017) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Placental TGF-β mRNA expression in infants with and without allergic disease. A, TGF-β mRNA expression (normalized to housekeeping gene, β-actin) as geometric means and 95% CIs for infants with allergic disease (solid bars) and those without allergic disease (open bars). B, Levels are also shown separately for male and female infants according to allergic status. Journal of Allergy and Clinical Immunology 2011 128, 886-887.e5DOI: (10.1016/j.jaci.2011.05.017) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Comparison of placental gene expression in male and female infants: Placental FOXP3 gene expression (mRNA) is shown (means + 95% CIs) for female (open bar) and male (solid bar) infants as indicated. Levels are displayed as geometric means and 95% CIs. Journal of Allergy and Clinical Immunology 2011 128, 886-887.e5DOI: (10.1016/j.jaci.2011.05.017) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Placental FOXP3 protein detection in fetal tissues. A-D, Formalin-fixed paraffin-embedded sections (4 μm) from 4 individuals are shown under 20× magnification after staining for FOXP3 (mouse monoclonal antibody clone 236A/E7 1 mg/mL used at 1:50) as described in the additional Methods in the Online Repository. Positive cells appear brown under bright field illumination. For further description, refer to Results provided earlier in the Online Repository. Journal of Allergy and Clinical Immunology 2011 128, 886-887.e5DOI: (10.1016/j.jaci.2011.05.017) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions