Chronic rhinosinusitis: Endotypes, biomarkers, and treatment response

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Presentation transcript:

Chronic rhinosinusitis: Endotypes, biomarkers, and treatment response Jose Gurrola, MD, Larry Borish, MD Journal of Allergy and Clinical Immunology Volume 140, Issue 6, Pages 1499-1508 (December 2017) DOI: 10.1016/j.jaci.2017.10.006 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Patterns of TH1/TH2/TH17 cytokine expression in samples from patients with CRSwNP: Benelux (A), Berlin (B), Adelaide (C), Beijing (D), Chengdu (E), and Tochigi (F). Reproduced with permission from Wang et al.7 Journal of Allergy and Clinical Immunology 2017 140, 1499-1508DOI: (10.1016/j.jaci.2017.10.006) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Tissue eosinophil distribution in NP samples. Eosinophils were counted in ten ×400 high-power fields. These figures display the range of distribution of the eosinophils enumerated in nasal polyps as a function of average (A) and peak (B) expression. For the distribution of eosinophil numbers, “[“ indicates inclusion of that number and “)” indicates less than that number. Reproduced with permission from Steinke et al.18 Journal of Allergy and Clinical Immunology 2017 140, 1499-1508DOI: (10.1016/j.jaci.2017.10.006) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions