Volume 59, Issue 6, Pages (June 2001)

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Volume 59, Issue 6, Pages 2267-2272 (June 2001) Dimethylglycine accumulates in uremia and predicts elevated plasma homocysteine concentrations David O. Mcgregor, Warwick J. Dellow, Michael Lever, Peter M. George, Richard A. Robson, Stephen T. Chambers Kidney International Volume 59, Issue 6, Pages 2267-2272 (June 2001) DOI: 10.1046/j.1523-1755.2001.00743.x Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 1 Betaine-homocysteine methyl transferase (BHMT) metabolic pathway: Glycine betaine (GB) is obtained from the diet or by conversion of dietary choline. BHMT transfers a methyl group from GB to homocysteine, producing methionine and N,N-dimethylglycine betaine (DMG) that is excreted in urine or metabolized to sarcosine by dimethylglycine dehydrogenase. Abbreviations are: CBS, cystathionine beta-synthetase; MTHFR, N5,N10-methylenetetrahydrofolate reductase. Kidney International 2001 59, 2267-2272DOI: (10.1046/j.1523-1755.2001.00743.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 2 Plasma DMG and homocysteine concentrations (N = 99, r = 0.42, P < 0.001). Kidney International 2001 59, 2267-2272DOI: (10.1046/j.1523-1755.2001.00743.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 3 Plasma DMG:GB ratio and plasma homocysteine (N = 99, r = 0.54, P < 0.001). Kidney International 2001 59, 2267-2272DOI: (10.1046/j.1523-1755.2001.00743.x) Copyright © 2001 International Society of Nephrology Terms and Conditions

Figure 4 Serum zinc and plasma homocysteine concentrations (N = 99, r = -0.31, P = 0.001). Kidney International 2001 59, 2267-2272DOI: (10.1046/j.1523-1755.2001.00743.x) Copyright © 2001 International Society of Nephrology Terms and Conditions