Classification by HtTKV0 and age at HtTKV0 predicts the change in eGFR over time in class 1 patients. Classification by HtTKV0 and age at HtTKV0 predicts.

Slides:



Advertisements
Similar presentations
Date of download: 7/11/2016 From: Cost-Effectiveness of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease Ann Intern Med. 2013;159(6):
Advertisements

Scatter Plots and Lines of Fit
Characteristics IgAN (n=28) ADPKD (n=37) Male (percentage) 21 (75.0)
Your First and Last Name* and Supervisor’s First and last name
Kuwabara et al. Am J Nephrol 2017;45:   (DOI: / )
Patient disposition for the double-blind study period.
Relationship between urinary TNF-α and RANTES excretion
Differential expression of select miRNAs was validated in a second cohort of patients. Differential expression of select miRNAs was validated in a second.
Pedigrees of the families of patients 1 and 2 show that the clinical phenotype co-segregates with compound heterozygous CLDN10 variants. Pedigrees of the.
TNT post hoc analysis: Improvement between baseline and final visit in estimated GFR by treatment group End point 10-mg atorvastatin 80-mg atorvastatin.
Nat. Rev. Nephrol. doi: /nrneph
Studies reporting the incident rate for all types of infections per 1000 patient days. Studies reporting the incident rate for all types of infections.
Several microRNAs are differentially expressed in the glomeruli between different types of kidney disease. Several microRNAs are differentially expressed.
Volume 72, Issue 5, Pages (September 2007)
Vanda Jorgetti, Luciene M. dos Reis, Susan M. Ott  Kidney International 
Matei Neagu, PhD, Daniel Coca, PhD, Albert C.M. Ong, DM 
Impact of risk factors and age of initiation of therapy on the distribution of lifespan gain. ‘National average risk’ refers to a cohort beginning at age.
The proportion of DCD donor kidneys discarded was correlated with the proportion of NBD donor kidneys discarded within DSAs (Pearson correlation coefficient.
The incidence of all cause graft failure, and death with a functioning graft was higher in patients who received a DCD donor transplant with total donor.
Susumu Takahashi, Kazuyoshi Okada, Mitsuru Yanai  Kidney International 
Your Kidneys May Outlive You
The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli  Richard J. Glassock, Andrew D. Rule  Kidney.
Obesity and type 2 diabetes forecasts.
Risk for BMI outcome (%)
How to interpret the eGFR in patients with small body surface area
Volume 53, Issue 4, Pages (April 1998)
Gender differences in diabetes prevalence in 2009 in the general Portuguese population patients and in patients with CAP. Diabetes prevalence is higher.
Long-term effects of spironolactone on proteinuria and kidney function in patients with chronic kidney disease  S. Bianchi, R. Bigazzi, V.M. Campese 
Correction to "Prevalence of abnormal serum vitamin D, PTH, calcium, and phosphorus in patients with chronic kidney disease: results of the study to evaluate.
U-shaped effect of eGFR and mortality
Volume 79, Issue 2, Pages (January 2011)
Risk factor Treatment GFR at baseline GFR at 5 years p Cadaveric donor
Trend of overall improvement in CKD risk categories after bariatric surgery using year 1 post-surgery as baseline. Trend of overall improvement in CKD.
Patient disposition. Patient disposition. AE, adverse event. *One patient died during the follow-up period. ^Four of the 12 discontinuations of treatment.
(A through C) Mean eGFR during follow-up according to treatment assignment in patients with normoalbuminuria (A), microalbuminuria (B), and macroalbuminuria.
Nowak et al. Am J Nephrol 2016;44: (DOI: / )
Three-year cumulative incidence of a gout diagnosis presented by level of kidney function and sex. Three-year cumulative incidence of a gout diagnosis.
Calcium sensing in podocytes
Predicted number of joint bleeds according to factor activity level and age group for patients with hemophilia A or B based on a regression model. Predicted.
Relative risk of a major coronary heart disease event (myocardial infarction incidence, fatal coronary heart disease, or coronary revascularization) for.
UMOD and ACSM2A expressions correlate with renal function.
Hemodialysis patients represent a tiny subset of all patients with heart disease. Hemodialysis patients represent a tiny subset of all patients with heart.
Vitamin K2 supplementation reduces dp-ucMGP but not dp-cMGP levels in dialysis patients. Vitamin K2 supplementation reduces dp-ucMGP but not dp-cMGP levels.
Box plots showing the relative difference in distribution of mtDNA copy number per cell between patients with ESRD and healthy control subjects frequency.
Representative photomicrographs of immunohistochemical staining for Wilms’ tumor 1 (WT1) and cleaved caspase-3 in mouse kidney sections at 10, 20, and.
Volume 76, Issue 6, Pages (September 2009)
Representative transaxial thin computed tomography (CT) sections at mid, mid-low, and low levels of the heart from a control subject (left) showing normal.
Adjusted means (±SD) of eGFR in relation to the histologic severity of nonalcoholic steatohepatitis (i.e., NASH/fibrosis stage increasing from 0 to 3)
Lifestyle intervention was associated with improved cardiorespiratory fitness. Lifestyle intervention was associated with improved cardiorespiratory fitness.
Ann M. O'Hare, MA, MD  American Journal of Kidney Diseases 
The development of regional ventricular dysfunction as measured by regional wall motion abnormalities (RWMA; abnormal regions) was associated with a greater.
Effect of randomized treatment on all renal events (top) and the composite of all renal events, macrovascular events, or all-cause mortality (bottom) according.
Cumulative mortality risk in patients with 48-h blood urea nitrogen (BUN) levels of ≥8 mg/dl or
Change in total kidney volume and renal function over 3 years of tolvaptan compared with matched control and their correlation for individual subjects.
Correlations among chronic kidney disease (CKD) classification, urinary adiponectin level, eGFR, and ACR. (A) Correlation between CKD classification and.
Among three residual kidney function (RKF) indices, only residual urine volume (UV) indicated an independent prognostic value in patients with UV≥0.1 or.
Brooks A. Keel, Ph.D., H.C.L.D.(A.B.B.)  Fertility and Sterility 
Plots of average estimated and measured GFR vs
Distribution of percent consistent facility aspirin use.
Changes in 44-hour interdialytic systolic BP as a function of change in echocardiographic volume parameter. Changes in 44-hour interdialytic systolic BP.
New dialysis starts in the United States by year in patients with and without diagnosis of diabetes. New dialysis starts in the United States by year in.
Bias with estimated GFR (eGFR) by age (years).
Correlation between change in blood pressure (BP) and a rapid annual decline in kidney function (≥3 mL/min/1.73 m2/year) (logistic regression) (n=7283).
Fistula and Survival Outcomes after Fistula Creation among Predialysis Chronic Kidney Disease Stage 5 Patients Miyamoto et al. Am J Nephrol 2017;45:  
Renal hemodynamics. Renal hemodynamics. GFR (A), effective renal plasma flow (ERPF; B), and filtration fraction (FF; C) in patients with diabetes and with.
Characteristics of persons with CKD without established risk factors versus those with CKD and diabetes. (A) Among participants of population-based studies.
Pancreas transplantation is performed at transplant centers within 56 of the 58 federally designated donor service areas (DSAs). Pancreas transplantation.
Organ quality (KDPI) of unilaterally discarded, deceased donor kidneys stratified by discard type (n=7625 kidneys), 2000–2015. Organ quality (KDPI) of.
Intersubject distribution of eGFR slope (left) and mGFR slope (right).
Two to 20 years: female patients, continued.
Presentation transcript:

Classification by HtTKV0 and age at HtTKV0 predicts the change in eGFR over time in class 1 patients. Classification by HtTKV0 and age at HtTKV0 predicts the change in eGFR over time in class 1 patients. (A) Subclassification of patients with class 1 ADPKD at baseline based on HtTKV limits for their age. Limits are defined based on estimated kidney growth rates of 1.5%, 3.0%, 4.5%, and 6.0%. (B) Slopes for men based on the model presented in Table 5. As a reference, the average eGFR at baseline (75 ml/min per 1.73 m2) and the average age at baseline (44 years) for all class 1 patients were used for the model. Estimated slopes (ml/min per 1.73 m2 per year) by subclass (A–E) are −0.23,−1.33, −2.63, −3.48, and −4.78, respectively, for men and 0.03, −1.13, −2.43, −3.29 and −4.58, respectively, for women (not plotted). Values for normal slope (*) were obtained from a population of healthy kidney donors.16 María V. Irazabal et al. JASN 2015;26:160-172 ©2015 by American Society of Nephrology