Hemodynamic Effects of l-Threo-3,4-Dihydroxyphenylserine (Droxidopa) in Hypotensive Individuals With Spinal Cord Injury Jill M. Wecht, EdD, Dwindally.

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Hemodynamic Effects of l-Threo-3,4-Dihydroxyphenylserine (Droxidopa) in Hypotensive Individuals With Spinal Cord Injury Jill M. Wecht, EdD, Dwindally Rosado-Rivera, EdD, Joseph P. Weir, PhD, Adrian Ivan, MS, Christina Yen, BS, William A. Bauman, MD Archives of Physical Medicine and Rehabilitation Volume 94, Issue 10, Pages 2006-2012 (October 2013) DOI: 10.1016/j.apmr.2013.03.028 Copyright © 2013 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 1 BL and supine observations for heart rate (A), SBP (B), and DBP (C); placebo (open circles), droxidopa 100mg (asterisks), droxidopa 200mg (open triangle), and droxidopa 400mg (closed squares). ↑=administration of placebo/droxidopa. The main effect for dose and the interaction effect were not significant; however, the main effect for position was significant for heart rate, SBP, and DBP: *P<.0001 compared with BL 1, 2, and 3. Archives of Physical Medicine and Rehabilitation 2013 94, 2006-2012DOI: (10.1016/j.apmr.2013.03.028) Copyright © 2013 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 2 Individual responses to the orthostatic change in heart rate (A), SBP (B), and DBP (C) when repositioning from supine to seated; placebo (open circles), droxidopa 100mg (asterisks), droxidopa 200mg (open triangle), and droxidopa 400mg (closed squares). Main effects for dose and position and the interaction effect were not significant. Archives of Physical Medicine and Rehabilitation 2013 94, 2006-2012DOI: (10.1016/j.apmr.2013.03.028) Copyright © 2013 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 3 Seated BL and seated postdrug/placebo heart rate (A), SBP (B), and DBP (C); placebo (open circles), droxidopa 100mg (asterisks), droxidopa 200mg (open triangle), and droxidopa 400mg (closed squares). *P<.05 versus placebo; τ=P<.05 versus 100mg droxidopa; δ=P<.05 versus 200mg droxidopa. Archives of Physical Medicine and Rehabilitation 2013 94, 2006-2012DOI: (10.1016/j.apmr.2013.03.028) Copyright © 2013 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 4 Average 4-hour SBP following placebo (open circles), droxidopa 100mg (asterisks), droxidopa 200mg (open triangle), and droxidopa 400mg (closed squares). The dashed line represents the WHO's threshold for hypotension in males (110mmHg). Archives of Physical Medicine and Rehabilitation 2013 94, 2006-2012DOI: (10.1016/j.apmr.2013.03.028) Copyright © 2013 American Congress of Rehabilitation Medicine Terms and Conditions