Progression of cartilage damage and meniscal pathology over 30 months is associated with an increase in radiographic tibiofemoral joint space narrowing.

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Presentation transcript:

Progression of cartilage damage and meniscal pathology over 30 months is associated with an increase in radiographic tibiofemoral joint space narrowing in persons with knee OA – the MOST study M.D. Crema, M.C. Nevitt, A. Guermazi, D.T. Felson, K. Wang, J.A. Lynch, M.D. Marra, J. Torner, C.E. Lewis, F.W. Roemer Osteoarthritis and Cartilage Volume 22, Issue 10, Pages 1743-1747 (October 2014) DOI: 10.1016/j.joca.2014.07.008 Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 This flow chart offers a graphic description of the selection process for the knees we studied. Tibiofemoral compartments with maximum grades in all subregions of any baseline MRI feature (cartilage damage, meniscal damage, or meniscal extrusion) were excluded since they cannot progress. Knees with a KL grade of 3 or higher at baseline were excluded from the analysis to avoid ceiling effects in regard to JSN increase. Osteoarthritis and Cartilage 2014 22, 1743-1747DOI: (10.1016/j.joca.2014.07.008) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Subregional division in WORMS. Ten tibiofemoral subregions are defined for cartilage assessment: the central (C) and posterior (P) femur medially and laterally, as well as the anterior (A), central (C), and posterior (P) tibia medially and laterally. The anterior (A) femur subregion is part of the patellofemoral compartment. Osteoarthritis and Cartilage 2014 22, 1743-1747DOI: (10.1016/j.joca.2014.07.008) Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions