Mucosal Healing Is Associated With Improved Long-term Outcomes of Patients With Ulcerative Colitis: A Systematic Review and Meta-analysis Shailja C.

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Presentation transcript:

Mucosal Healing Is Associated With Improved Long-term Outcomes of Patients With Ulcerative Colitis: A Systematic Review and Meta-analysis Shailja C. Shah, Jean-Frederic Colombel, Bruce E. Sands, Neeraj Narula Clinical Gastroenterology and Hepatology Volume 14, Issue 9, Pages 1245-1255.e8 (September 2016) DOI: 10.1016/j.cgh.2016.01.015 Copyright © 2016 AGA Institute Terms and Conditions

Figure 1 Flow diagram of study search. Clinical Gastroenterology and Hepatology 2016 14, 1245-1255.e8DOI: (10.1016/j.cgh.2016.01.015) Copyright © 2016 AGA Institute Terms and Conditions

Figure 2 Association of MH1 and long-term CR. M-H, mucosal healing. Clinical Gastroenterology and Hepatology 2016 14, 1245-1255.e8DOI: (10.1016/j.cgh.2016.01.015) Copyright © 2016 AGA Institute Terms and Conditions

Figure 3 Association of MH1 and colectomy-free rate at follow-up. M-H, mucosal healing. Clinical Gastroenterology and Hepatology 2016 14, 1245-1255.e8DOI: (10.1016/j.cgh.2016.01.015) Copyright © 2016 AGA Institute Terms and Conditions

Figure 4 Association of MH1 and long-term MH. M-H, mucosal healing. Clinical Gastroenterology and Hepatology 2016 14, 1245-1255.e8DOI: (10.1016/j.cgh.2016.01.015) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 1 Association of MH1 and long-term CS-free CR. M-H, mucosal healing. Clinical Gastroenterology and Hepatology 2016 14, 1245-1255.e8DOI: (10.1016/j.cgh.2016.01.015) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 2 Funnel plot assessing publication bias of long-term CR. OR, odds ratio; SE, standard error. Clinical Gastroenterology and Hepatology 2016 14, 1245-1255.e8DOI: (10.1016/j.cgh.2016.01.015) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 3 Association of MH1 and long-term CR: biologic therapy vs non-biologic therapy. M-H, mucosal healing. Clinical Gastroenterology and Hepatology 2016 14, 1245-1255.e8DOI: (10.1016/j.cgh.2016.01.015) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 4 Association of MH1 and colectomy-free rate at follow-up: biologic therapy vs non-biologic therapy. M-H, mucosal healing. Clinical Gastroenterology and Hepatology 2016 14, 1245-1255.e8DOI: (10.1016/j.cgh.2016.01.015) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 5 Association of MH1 and long-term MH: biologic therapy vs non-biologic therapy. M-H, mucosal healing. Clinical Gastroenterology and Hepatology 2016 14, 1245-1255.e8DOI: (10.1016/j.cgh.2016.01.015) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 6 Association of MH1 and long-term CR: RCTs vs non-RCTs. M-H, mucosal healing. Clinical Gastroenterology and Hepatology 2016 14, 1245-1255.e8DOI: (10.1016/j.cgh.2016.01.015) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 7 Association of MH1 and colectomy-free rate at follow-up: RCTs vs non-RCTs. M-H, mucosal healing. Clinical Gastroenterology and Hepatology 2016 14, 1245-1255.e8DOI: (10.1016/j.cgh.2016.01.015) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 8 Association of MH1 and CR at follow-up <2 y vs ≥2 y. M-H, mucosal healing. Clinical Gastroenterology and Hepatology 2016 14, 1245-1255.e8DOI: (10.1016/j.cgh.2016.01.015) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 9 Association of MH1 and colectomy-free rate at follow-up <2 y vs ≥2 y. M-H, mucosal healing. Clinical Gastroenterology and Hepatology 2016 14, 1245-1255.e8DOI: (10.1016/j.cgh.2016.01.015) Copyright © 2016 AGA Institute Terms and Conditions

Supplementary Figure 10 Association of MH1 and MH at follow-up <2 y vs ≥2 y. M-H, mucosal healing. Clinical Gastroenterology and Hepatology 2016 14, 1245-1255.e8DOI: (10.1016/j.cgh.2016.01.015) Copyright © 2016 AGA Institute Terms and Conditions