Osteoarthritis and Cartilage

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Presentation transcript:

Osteoarthritis and Cartilage Elevated LDL cholesterol-levels during experimental OA leads to increased synovial thickening , s100a8/9 production and ectopic bone formation W. de Munter, M.H. van den Bosch, A.W. Sloetjes, T. Vogl, J. Roth, P.M. van der Kraan, W.B. van der Berg, P.L. van Lent Osteoarthritis and Cartilage Volume 22, (April 2014) DOI: 10.1016/j.joca.2014.02.847 Copyright © 2014 Terms and Conditions

Figure 1. LDL cholesterol correlates with ectopic bone formation in the medial collateral ligament in experimental OA. Four representative microphotographs of the medial side of the knee joint, 36 days after induction of OA by intra-articular injection of collagenase. Both WT and ApoE deficient mice received a normal or a cholesterol-rich diet, starting 18 days before induction of OA. Saf O - Fast Green staining. Osteoarthritis and Cartilage 2014 22, DOI: (10.1016/j.joca.2014.02.847) Copyright © 2014 Terms and Conditions