Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent Marialbert Acosta-Herrera,

Slides:

Advertisements

Similar presentations

Maria Pino-Yanes, PhD, Neeta Thakur, MD, MPH, Christopher R

Advertisements

Rasika A. Mathias, ScD, Audrey V

Factors associated with degree of atopy in Latino children in a nationwide pediatric sample: The Genes-environments and Admixture in Latino Asthmatics.

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients Xingnan Li, PhD, MS, Gregory A. Hawkins,

Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans Rachel A. Myers, PhD, Blanca E. Himes,

Cosmopolitan and ethnic-specific replication of genetic risk factors for asthma in 2 Latino populations Joshua M. Galanter, MD, Dara Torgerson, PhD,

Katherine A. Drake, PhD, Dara G. Torgerson, PhD, Christopher R

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

Clarification concerning amoxicillin skin testing

Cristina Teodosio, MSc, Andrés C

Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients Xingnan Li, PhD, MS, Gregory A. Hawkins,

Role of the basophil activation test in the diagnosis of local allergic rhinitis Enrique Gómez, PhD, Paloma Campo, MD, PhD, Carmen Rondón, MD, PhD, Esther.

David A. Khan, MD Journal of Allergy and Clinical Immunology

Polymorphisms in the myosin light chain kinase gene that confer risk of severe sepsis are associated with a lower risk of asthma Li Gao, MD, PhD, Audrey.

Genome-wide association study and admixture mapping identify different asthma- associated loci in Latinos: The Genes-environments & Admixture in Latino.

Genome-wide association study and admixture mapping reveal new loci associated with total IgE levels in Latinos Maria Pino-Yanes, PhD, Christopher R.

Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans Rachel A. Myers, PhD, Blanca E. Himes,

Is 9 more than 2 also in allergic airway inflammation?

Rasika A. Mathias, ScD, Audrey V

Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide: A random-sample population study Asger Sverrild, MD, Celeste Porsbjerg,

Albert M. Levin, PhD, Rasika A

Katherine A. Drake, PhD, Dara G. Torgerson, PhD, Christopher R

Rising prevalence of asthma is sex-specific in a US farming population

Component-resolved diagnosis of wheat flour allergy in baker's asthma

Nasal allergen provocation test with multiple aeroallergens detects polysensitization in local allergic rhinitis Carmen Rondón, MD, PhD, Paloma Campo,

An epigenome-wide association study of total serum IgE in Hispanic children Wei Chen, PhD, Ting Wang, PhD, Maria Pino-Yanes, PhD, Erick Forno, MD, MPH,

S. Melkorka Maggadottir, MD, Jin Li, PhD, Joseph T

Lieuwe D. Bos, MSc, PhD, Peter J. Sterk, MD, PhD, Stephen J

James J. Yang, PhD, Esteban G

The nuclear factor I/A (NFIA) gene is associated with the asthma plus rhinitis phenotype Marie-Hélène Dizier, PhD, Patricia Margaritte-Jeannin, PhD,

Joseph A. Odhiambo, MMed, Hywel C. Williams, PhD, Tadd O

Xingnan Li, PhD, Timothy D. Howard, PhD, Siqun L

Successful management of mite-allergic asthma with modified extracts of Dermatophagoides pteronyssinus and Dermatophagoides farinae in a double-blind,

Jewlya Lynn, PhD, Sophie Oppenheimer, MS, MPH, Lorena Zimmer, MA

Genome-wide ancestry association testing identifies a common European variant on 6q14.1 as a risk factor for asthma in African American subjects Dara.

Cosmopolitan and ethnic-specific replication of genetic risk factors for asthma in 2 Latino populations Joshua M. Galanter, MD, Dara Torgerson, PhD,

Jon Genuneit, MD, MSc Journal of Allergy and Clinical Immunology

Berta Almoguera, PhD, Lyam Vazquez, MD, Frank Mentch, PhD, Michael E

Conundrums in childhood asthma severity, control, and health care use: Puerto Rico versus Rhode Island Cynthia A. Esteban, MSN, MPH, Robert B. Klein,

Food allergy: A review and update on epidemiology, pathogenesis, diagnosis, prevention, and management Scott H. Sicherer, MD, Hugh A. Sampson, MD Journal.

Biosimilars and drug development in allergic and immunologic diseases

Daphne Koinis-Mitchell, PhD, Timothy Craig, DO, Cynthia A

Factors associated with degree of atopy in Latino children in a nationwide pediatric sample: The Genes-environments and Admixture in Latino Asthmatics.

A cluster-randomized trial shows telephone peer coaching for parents reduces children's asthma morbidity Jane M. Garbutt, MB, ChB, Yan Yan, MD, PhD,

Genetic basis of the latex-fruit syndrome: Association with HLA class II alleles in a Spanish population Carlos Blanco, MD, PhD, Florentino Sánchez-García,

Airway hyperresponsiveness to mannitol and methacholine and exhaled nitric oxide: A random-sample population study Asger Sverrild, MD, Celeste Porsbjerg,

Maria Pino-Yanes, PhD, Neeta Thakur, MD, MPH, Christopher R

The ANO3/MUC15 locus is associated with eczema in families ascertained through asthma Marie-Hélène Dizier, PhD, Patricia Margaritte-Jeannin, PhD, Anne-Marie.

Autophagy: Nobel Prize 2016 and allergy and asthma research

Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility.

Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment

Mark Granada, MD, Jemma B. Wilk, DSc, Marina Tuzova, MD, PhD, David P

Erick Forno, MD, MPH, Edna Acosta-Pérez, PhD, MSc, John M

Inhaled corticosteroid treatment modulates ZNF432 gene variant’s effect on bronchodilator response in asthmatics Ann Chen Wu, MD, MPH, Blanca E. Himes,

ALOX5AP and LTA4H polymorphisms modify augmentation of bronchodilator responsiveness by leukotriene modifiers in Latinos Haig Tcheurekdjian, MD, Marc.

Pei-Song Gao, MD, PhD, Nicholas M

Suzanne Havstad, MA, Ganesa Wegienka, PhD, Edward M

Local allergic rhinitis: Allergen tolerance and immunologic changes after preseasonal immunotherapy with grass pollen Carmen Rondón, MD, PhD, Natalia.

Genome-wide interaction study of dust mite allergen on lung function in children with asthma Erick Forno, MD, MPH, Joanne Sordillo, MD, MPH, John Brehm,

Susan A. Rudders, MD, Sarah A. Arias, PhD, Carlos A

Nasal inflammatory mediators and specific IgE production after nasal challenge with grass pollen in local allergic rhinitis Carmen Rondón, MD, PhD, Javier.

IL-4/IL-13 pathway genetics strongly influence serum IgE levels and childhood asthma Michael Kabesch, MD, Michaela Schedel, MSc, David Carr, MSc, Bernd.

Genome-wide association studies of asthma indicate opposite immunopathogenesis direction from autoimmune diseases Xingnan Li, PhD, Elizabeth J. Ampleford,

Genetic variants in the GATA3 gene are not associated with asthma and atopic diseases in German children Kathrin Suttner, MSc, Martin Depner, MSc, Norman.

Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis Elizabeth T. Jensen,

Asthma: The past, future, environment, and costs

Environmental factors and eosinophilic esophagitis

Paradoxical psoriasis following anti–TNF therapy in ankylosing spondylitis: A population- based cohort study Jung Min Bae, MD, PhD, Hyuck Sun Kwon, MD,

Natural history of cow’s milk allergy

IL-1 receptor–associated kinase 3 gene (IRAK3) variants associate with asthma in a replication study in the Spanish population María Pino-Yanes, MSc,

Presentation transcript:

Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent Marialbert Acosta-Herrera, MSc, Maria Pino-Yanes, PhD, Shwu-Fan Ma, PhD, Amalia Barreto-Luis, BS, Almudena Corrales, CLT, José Cumplido, MD, Eva Pérez-Rodríguez, MD, Paloma Campo, MD, PhD, Celeste Eng, BS, José Carlos García-Robaina, MD, PhD, Inés Quintela, MSc, Jesús Villar, MD, PhD, Miguel Blanca, MD, PhD, Ángel Carracedo, MD, PhD, Teresa Carrillo, MD, PhD, Joe G.N. Garcia, MD, Dara G. Torgerson, PhD, Esteban G. Burchard, MD, MPH, Carlos Flores, PhD Journal of Allergy and Clinical Immunology Volume 136, Issue 4, Pages 1116-1118.e9 (October 2015) DOI: 10.1016/j.jaci.2015.04.025 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Regional plots of association results in the discovery sample (upper panel) and the GABRIEL (middle panel) and EVE (lower panel) consortia. The −log10 transformed P values for association tests are plotted as symbols according to their functional annotation. The SNP rs number indicated on the plot denotes the result for the most significantly associated SNP with asthma risk. The results for the remaining SNPs are color coded to reflect their degree of LD with the most significant SNP based on pairwise r2 values from the European population of the 1KGP. Estimated recombination rates (light blue line) are plotted on the right y-axis. Journal of Allergy and Clinical Immunology 2015 136, 1116-1118.e9DOI: (10.1016/j.jaci.2015.04.025) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Flow chart providing an overall description of the study design. GALA I, Genetics of Asthma in Latino Americans; GALA II, Genes-Environments & Admixture in Latino Americans; GOA I, Genetics of Asthma study in the Spanish population; GOA II, Genetics of Asthma study in the Spanish population II; GOAM, Genetics of Asthma study in the Spanish population from Malaga. Journal of Allergy and Clinical Immunology 2015 136, 1116-1118.e9DOI: (10.1016/j.jaci.2015.04.025) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions