Proximity to blue spaces and risk of infection with Pseudomonas aeruginosa in cystic fibrosis: A case–control analysis  Pieter C. Goeminne, Tim S. Nawrot, Kris De Boeck, Ben Nemery, Lieven J. Dupont  Journal of Cystic Fibrosis  Volume 14, Issue 6, Pages 741-747 (November 2015) DOI: 10.1016/j.jcf.2015.04.004 Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 1 Illustration of the determination of beeline distance and shortest walking distance between home and blue spaces. Blue lines: “blue space”; White lines: roads; Red square: home address; Single arrows: shortest beeline distance options (full single arrow shows the shortest choice – 71m, dotted single arrow shows the longest of both choices – 129m); Green double arrow lines: shortest walking distance possibilities (full double arrow line shows the shortest choice — 132m; dotted double arrow lines (167 and 217m) are longer than the full line). Journal of Cystic Fibrosis 2015 14, 741-747DOI: (10.1016/j.jcf.2015.04.004) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 2 Map of Belgium with the location of the residence of 28 cystic fibrosis patients who were never infected by Pseudomonas aeruginosa and 28 cystic fibrosis patients with chronic colonization by P. aeruginosa: Red dots are patients who were never infected by P. aeruginosa; Green dots are patients who have chronic P. aeruginosa colonization. The dashed line is the limit between the Flemish and Walloon regions of Belgium. Journal of Cystic Fibrosis 2015 14, 741-747DOI: (10.1016/j.jcf.2015.04.004) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 3 Beeline distance between home and the nearest water source in 28 cystic fibrosis patients who were never infected by Pseudomonas aeruginosa and 28 cystic fibrosis patients with chronic colonization by P. aeruginosa: Horizontal lines represent mean values and standard deviation; p-value obtained by unpaired Student's t-test. Journal of Cystic Fibrosis 2015 14, 741-747DOI: (10.1016/j.jcf.2015.04.004) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions

Fig. 4 Walking distance between home and the nearest water source in 28 cystic fibrosis patients who were never infected by Pseudomonas aeruginosa and 28 cystic fibrosis patients with chronic colonization by P. aeruginosa: Horizontal lines represent mean values and standard deviation; p-value obtained by unpaired Student's t-test. Journal of Cystic Fibrosis 2015 14, 741-747DOI: (10.1016/j.jcf.2015.04.004) Copyright © 2015 European Cystic Fibrosis Society. Terms and Conditions