Modulating kidney transplant interstitial fibrosis and tubular atrophy: is the RAAS an important target? Hatem Amer, Matthew D. Griffin Kidney International Volume 85, Issue 2, Pages 240-243 (January 2014) DOI: 10.1038/ki.2013.400 Copyright © 2014 International Society of Nephrology Terms and Conditions
Figure 1 Illustration of current understanding of the predisposing, causative, and common mechanistic pathways involved in the pathogenesis of interstitial fibrosis and tubular atrophy of kidney transplants in the current era. eGFR, estimated glomerular filtration rate; ER, endoplasmic reticulum; TGF-β, transforming growth factor-β. Kidney International 2014 85, 240-243DOI: (10.1038/ki.2013.400) Copyright © 2014 International Society of Nephrology Terms and Conditions