Modulating kidney transplant interstitial fibrosis and tubular atrophy: is the RAAS an important target? Hatem Amer, Matthew D. Griffin Kidney International

Slides:

Advertisements

Similar presentations

Chapter 1: Definition and classification of CKD Kidney International Supplements Volume 3, Issue 1, Pages (January 2013) DOI: /kisup

Advertisements

Melamine toxicity: one more culprit in calcium kidney lithiasis

The Case | Renal failure in a bodybuilder athlete

Summary of KDIGO 2012 CKD Guideline: behind the scenes, need for guidance, and a framework for moving forward Adeera Levin, Paul E. Stevens Kidney International

Biomarkers in kidney fibrosis: are they useful?

Prehypertension and chronic kidney disease: the ox or the plow?

Volume 80, Issue 10, Pages (November 2011)

John P. Middleton, Patrick H. Pun Kidney International

Volume 77, Issue 1, Pages 6-8 (January 2010)

EGFR signaling in renal fibrosis

Volume 78, Issue 8, Pages (October 2010)

Volume 137, Issue 1, Pages (July 2009)

Volume 77, Issue 8, Pages (April 2010)

The implications of anatomical and functional changes of the aging kidney: with an emphasis on the glomeruli Richard J. Glassock, Andrew D. Rule Kidney.

Volume 77, Issue 1, Pages 5-6 (January 2010)

Comorbidity and confounding in end-stage renal disease

Volume 74, Issue 3, Pages (August 2008)

Lipid redistribution in renal dysfunction

Volume 73, Issue 7, Pages (April 2008)

Nephrology Crosswords: Hemodialysis

Predicting an allograft's fate

The role of protein kinase C activation in diabetic nephropathy

Timothy A. Sutton, Pierre C. Dagher Kidney International

U-shaped effect of eGFR and mortality

Saulo Klahr, Jeremiah J. Morrissey Kidney International

Melamine toxicity: one more culprit in calcium kidney lithiasis

Infected glomerulus Kidney International

A physician's perseverance uncovers problems in a key nephrology study

Can we prevent donor-specific antibodies from developing after ABO-incompatible kidney transplantation? Lionel Rostaing, Nassim Kamar Kidney International

Volume 69, Issue 12, Pages (June 2006)

Volume 69, Issue 3, Pages (February 2006)

Volume 85, Issue 5, Pages (May 2014)

Nephrology Crossword: Peritoneal Dialysis

Volume 67, Issue 1, Pages (January 2005)

Methods for guideline development

Twist: a new link from hypoxia to fibrosis

Environmental exposure to lead and progressive diabetic nephropathy in patients with type II diabetes J.-L. Lin, D.-T. Lin-Tan, C.-C. Yu, Y.-J. Li, Y.-Y.

Old friends form alliance against podocytes

Volume 85, Issue 1, Pages 3-4 (January 2014)

CD4+ T cells: a potential player in renal fibrosis

Nephrology Crossword: Glomerulonephritis

Volume 71, Issue 4, Pages (February 2007)

Volume 85, Issue 5, Pages (May 2014)

Volume 80, Issue 3, Pages (August 2011)

A man with a hole in his penis

Volume 82, Issue 9, Pages (November 2012)

The treatment of acute interstitial nephritis: More data at last

Volume 74, Issue 9, Pages (November 2008)

Immunity unmasks APOL1 in collapsing glomerulopathy

Organ transplantation goes to the movies

Does equal care give equal outcomes?

Volume 80, Issue 10, Pages (November 2011)

Volume 74, Issue 3, Pages (August 2008)

Is complement a target for therapy in renal disease?

David A. Ferenbach, David C. Kluth, Jeremy Hughes Kidney International

The Case | Peculiar fibrous nodules in a renal transplant biopsy

Volume 70, Issue 5, Pages (September 2006)

Kathryn J. Wiggins, Darren J. Kelly Kidney International

Volume 75, Issue 7, Pages (April 2009)

Adiponectin: good, bad, or just plain ugly?

Volume 75, Issue 6, Pages (March 2009)

Hisataka Kobayashi, Peter L. Choyke Kidney International

The international realities of live donor kidney transplantation

Abby S. Kazley, Kit N. Simpson, Kenneth D. Chavin, Prabhakar Baliga

Volume 75, Issue 8, Pages (April 2009)

Interstitial fibrosis: tubular hypothesis versus glomerular hypothesis

The Ebf1 knockout mouse and glomerular maturation

Renoprotection with vitamin D: Specific for diabetic nephropathy?

Ronen Levi, Justin Silver Kidney International

Volume 86, Issue 2, Pages (August 2014)

Presentation transcript:

Modulating kidney transplant interstitial fibrosis and tubular atrophy: is the RAAS an important target? Hatem Amer, Matthew D. Griffin Kidney International Volume 85, Issue 2, Pages 240-243 (January 2014) DOI: 10.1038/ki.2013.400 Copyright © 2014 International Society of Nephrology Terms and Conditions

Figure 1 Illustration of current understanding of the predisposing, causative, and common mechanistic pathways involved in the pathogenesis of interstitial fibrosis and tubular atrophy of kidney transplants in the current era. eGFR, estimated glomerular filtration rate; ER, endoplasmic reticulum; TGF-β, transforming growth factor-β. Kidney International 2014 85, 240-243DOI: (10.1038/ki.2013.400) Copyright © 2014 International Society of Nephrology Terms and Conditions