Viperin−/− mice have high levels of pro-inflammatory cytokines but low levels of Th2 cytokines. Viperin−/− mice have high levels of pro-inflammatory cytokines.

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Viperin−/− mice have high levels of pro-inflammatory cytokines but low levels of Th2 cytokines. Viperin−/− mice have high levels of pro-inflammatory cytokines but low levels of Th2 cytokines. Serum samples from individual mice used in CD4 T-cell depletion experiments (Fig 1) were analyzed by multiplex Luminex assay (36-plex). (A) Heat map of log-transformed analyte concentration values. (B) Median-centered serum concentrations of Th2 cytokines (pg/ml). (C) IL-18 and IL-22 median-centered serum levels (pg/ml). The results are representative of three independent experiments (n = 11–12 mice per group) and analyzed by Mann–Whitney nonparametric one-tailed t test for panels B and C (*P < 0.05, **P < 0.01, and ***P < 0.001). Guillaume Carissimo et al. LSA 2019;2:e201900298 © 2019 Carissimo et al.