Powering Tumor Metastasis with Recycled Fuel Mien-Chie Hung, Riyao Yang, Yutong Sun  Cancer Cell  Volume 30, Issue 3, Pages 374-375 (September 2016) DOI: 10.1016/j.ccell.2016.08.014 Copyright © 2016 Terms and Conditions

Figure 1 The Golgi Resident Protein GOLM1 Promotes the Recycling of Endocytosed EGFR After entering the cell, ligand-occupied EGFRs are delivered to the Rab5-positive early endosome, where some of them are sorted either to MVB and lysosome for degradation or to the nucleus by retrograde transport through Golgi and ER for DNA repair or regulation of gene expression. Some EGFRs recognized by GOLM1 are dispatched from TGN and move from the early endosome to the recycling endosome by a process requiring GOLM1 interaction with Rab11, eventually being transported back to the cell surface. In HCC cells, GOLM1 is overexpressed, leading to excess EGFR recycling and signaling that promote tumor metastasis. Cancer Cell 2016 30, 374-375DOI: (10.1016/j.ccell.2016.08.014) Copyright © 2016 Terms and Conditions