High‐fat diet augments gut permeability, metabolic endotoxemia, and systemic inflammation High‐fat diet augments gut permeability, metabolic endotoxemia,

Slides:

Advertisements

Similar presentations

Hyp mice show hypertension and increased NCC expression and phosphorylation A–ESerum intact Fgf23 concentration (A, n = 8–9, Student's t‐test, *P =

Advertisements

Impact of triple combination of gemcitabine‐based chemoirradiation with anti‐PD‐L1 in the KPC tumor allograft Impact of triple combination of gemcitabine‐based.

Systemic inflammation activates the exosomal machinery in the choroid plexus Systemic inflammation activates the exosomal machinery in the choroid plexus.

Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice Metabolic effects of TUG‐891 are reduced or absent in GPR120‐deficient mice.

Neuro‐inflammatory cytokines, brain microglial activation, and working memory deficits are normalized using LV.IDS.ApoEII, but not LV.IDS in MPS II mice.

The gene encoding TP53INP1 is expressed in pancreatic endocrine cells A, B(A, B) Immunocytofluorescent staining of TP53INP1 (red) and insulin (green) in.

PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection PbA‐specific CD4 T‐cell responses are maximal at day 6 post‐pRBC infection Proportion.

IFNα, but not IFNλ, treatment induces cytokine secretion from human immune cells IFNα, but not IFNλ, treatment induces cytokine secretion from human immune.

Control of IL‐6 synthesis by ζPKC and RelA Ser311 phosphorylation.

TFE3 regulates glucose homeostasis

AAV8‐hAAT‐FGF21 treatment improves liver fibrosis

Metabolic profile of Tfe3 KO mice fed a HFD

Treatment with FGF21‐encoding vectors reverses hepatic steatosis and fibrosis Treatment with FGF21‐encoding vectors reverses hepatic steatosis and fibrosis.

Fstl1 promotes cardiac fibroblasts proliferation via the ERK1/2‐dependent pathway Fstl1 promotes cardiac fibroblasts proliferation via the ERK1/2‐dependent.

Metabolic profile of Tfe3 KO mice

Preceding knockdown of FoxO3 reduces inhibitory effect of UCN‐01 on human lung fibroblast proliferation and myofibroblast transdifferentiation in response.

Patients with Kawasaki disease but not those with mimicking conditions have significantly elevated serum and urine levels of meprin A and filamin C, which.

Increased IFNγ producing CD4+ T cells in the spleen drives the enhanced splenic IFNγ on 6 dpi during concurrent co‐infection Increased IFNγ producing CD4+

Supraphysiological ARSA activity in LV.hARSA‐injected NHP

Stat3 promotes lung fibrosis and collagen synthesis independent of Smad3.A.Masson's trichrome stained sections of lung from gp130wt (wt), Smad3−/− (Smad3−/−),

TFE3 prevents diet‐induced obesity and metabolic syndrome

Expression of PD‐1 on PBMC and malignant exudate T cells

Integrated protein co‐expression and differential expression across the ALS‐FTD disease continuum Integrated protein co‐expression and differential expression.

TR specifically inhibits NLRP3 inflammasome activation

Combination of OTX‐015 and PD does not induce overt toxicity

PERK activator treatment protects neurite network

Neuro‐inflammatory cytokines, brain microglial activation, and working memory deficits are normalized using LV.IDS.ApoEII, but not LV.IDS in MPS II mice.

WT‐HSCT, LV. IDS, and LV. IDS

Treatment with FGF21‐encoding vectors reverses hepatic steatosis and fibrosis Treatment with FGF21‐encoding vectors reverses hepatic steatosis and fibrosis.

Intra‐eWAT administration of FGF21 vectors in ob/ob mice

Nec‐1 inhibits the phosphorylation and aggregation of tau

IR induces cellular damage and a loss of nerves and SOX2 and SOX2+ progenitors can replenish mouse acinar cells in response to cholinergic mimetics IR.

Treatment with AAV8‐hAAT‐FGF21 improves insulin sensitivity and glucose tolerance Treatment with AAV8‐hAAT‐FGF21 improves insulin sensitivity and glucose.

Lipogenic genes and SREBP1 protein are upregulated in HF‐R

SPP1 and TNC are induced by chemotherapy via JNK signaling

Normal priming and expansion of functional T cells in the spleen during concurrent co‐infection Normal priming and expansion of functional T cells in the.

The preventive role of TR in HFD‐treated mice

IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice IL‐23‐induced psoriasis‐like skin disease is ameliorated in IL‐23−/− mice ARepresentative.

LV.IDS and LV.IDS.ApoEII improve brain‐specific IDS activity and express supra‐physiological levels of active IDS in peripheral organs LV.IDS and LV.IDS.ApoEII.

Hccs downregulation induces apoptosome‐independent caspase‐9 activation in mitochondria.A–C.TUNEL assays on st30 embryos co‐injected with hccs‐MO and Apaf1‐MO.

Safety profile of reversibly immortalised human mesoangioblasts

AAV8‐hAAT‐FGF21‐mediated increased energy expenditure and decreased fat accumulation in iBAT and iWAT AAV8‐hAAT‐FGF21‐mediated increased energy expenditure.

Impact of ONX 0914 on abundance and dissemination of monocytes/macrophages during CVB3 infection Impact of ONX 0914 on abundance and dissemination of monocytes/macrophages.

EnAd‐EpCAMBiTE shows reproducible activity within an expanded cohort of patient malignant peritoneal and pleural exudates EnAd‐EpCAMBiTE shows reproducible.

GPR120 deficiency alters the expression of genes involved in glucose and lipid metabolism in BAT GPR120 deficiency alters the expression of genes involved.

Effect of memantine on Klk7‐dependent Aβ degradation activity

Vitreous concentrations of angiopoietins in patients newly diagnosed with retinal diseases and cell model of barrier breakdown testing the interaction.

Quantification of phenotypes by genes and developmental stage

NOD2 deletion exacerbates diet‐induced bacterial translocation, inflammation, and impairs insulin action in the liver A–CQuantification of bacterial DNA.

MiR‐34a‐5p functionally contributes to arrested lung alveolarization in response to hyperoxia miR‐34a‐5p functionally contributes to arrested lung alveolarization.

Therapeutic role of TR in HFD‐established diabetic mice

DHEA shortens circadian period

P2X4R blockade increases autoimmune inflammation

Etifoxine modulation of T‐cell activity during EAE

UCN‐01 inhibits FoxO3 inactivation in human lung fibroblasts stimulated with growth factors UCN‐01 inhibits FoxO3 inactivation in human lung fibroblasts.

Therapeutic activity of gal‐encapsulated cytotoxic drugs on tumor xenografts Therapeutic activity of gal‐encapsulated cytotoxic drugs on tumor xenografts.

Tissue‐specific differences in the levels of CoQ9, CoQ10, and DMQ9, and in the DMQ9/CoQ9 ratio after β‐RA treatment in Coq9R239X mice Tissue‐specific differences.

(A) Observed significant protein fold‐changes during the fed–fasting transition in C57BL/6J (B6) and 129Sv (S9) mice fed with a normal diet (T0). (A) Observed.

AOX modifies RISP assembly and rescues mitochondrial respiration in tissue‐specific fashion AOX modifies RISP assembly and rescues mitochondrial respiration.

FGFR1 and TGFβ signaling activity in smooth muscle cells in a mouse atherosclerosis model FGFR1 and TGFβ signaling activity in smooth muscle cells in a.

The oligoclonal antibody overcomes the C797S mutation‐mediated resistance to osimertinib The oligoclonal antibody overcomes the C797S mutation‐mediated.

UCN‐01 inhibits human IPF lung fibroblast pathological phenotypes and attenuates lung fibrosis induced by bleomycin injury UCN‐01 inhibits human IPF lung.

Bazedoxifene suppresses IL11‐mediated STAT3 signaling activity in human cancer cell lines and patient‐derived colon cancer primary cultures and organoids.

The GBS hemolytic pigment/lipid toxin induces caspase 1 activation and pyroptosis THP‐1 macrophages were treated with GBS pigment, and caspase 1 activation.

Niacin suppresses pro‐inflammatory cytokine expression in macrophages in DSS‐induced colitis in mice Niacin suppresses pro‐inflammatory cytokine expression.

Mice fed GP-SPI diet show improved fasting glucose and oral glucose tolerance. Mice fed GP-SPI diet show improved fasting glucose and oral glucose tolerance.

Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance A–DThe number of ampicillin‐resistant E. coli.

Defective NOD2 peptidoglycan sensing promotes diet‐induced inflammation, dysbiosis, and insulin resistance APrincipal coordinates analysis (PCoA) performed.

Prostaglandin E2 attenuates the host antitumor immunity to promote the HFD-induced HCC development. Prostaglandin E2 attenuates the host antitumor immunity.

Fig. 3. Effects of SFN in mice with diet-induced diabetes.

Presentation transcript:

High‐fat diet augments gut permeability, metabolic endotoxemia, and systemic inflammation High‐fat diet augments gut permeability, metabolic endotoxemia, and systemic inflammation Concentration of gut‐absorbed Evans Blue in serum 24 h after oral administration in regular‐chow diet (RD)‐ and high‐fat diet (HFD)‐fed mice, treated with vehicle or with antibiotic; n = 6 (RD), 5 (HFD), 5 (HFD+AB), 5 (RD+AB); CI 99%.Activation of PRRs induced by stimulation with serum isolated from mice fed RD or HFD for 7 weeks and receiving vehicle or neomycin for 3 weeks; fold RD; n = 3 for all groups; CI 99%.Serum cytokine profiles determined by Bio‐Plex assay (Bio‐Rad) of IL‐1β, n = 11 (RD), 12 (HFD), 12 (HFD+AB), 11 (RD+AB); CI 95%; IL‐6, n = 11 (RD), 12 (HFD), 12 (HFD+AB), 11 (RD+AB), CI 99.9%; TNF‐α, n = 11 for all groups, CI 99%; IL‐17A, n = 11 (RD), 12 (HFD), 12 (HFD+AB), 11 (RD+AB), CI 95%; and IFN‐γ, n = 12 for all groups, CI 95%. *n.d. = not detected.mRNA expression of Il1b, n = 5 (RD), 7 (HFD), 7 (HFD+AB), 3 (RD+AB), CI 95%; Il6, n = 5 (RD), 5 (HFD), 4 (HFD+AB), 4 (RD+AB), CI 95%; Tnfa, n = 6 (RD), 9 (HFD), 4 (HFD+AB), 5 (RD+AB), CI 95%; and Vegfa, n = 6 (RD), 5 (HFD), 5 (HFD+AB), 6 (RD+AB), CI 95% in choroids. Data information: All comparisons between groups are analyzed using one‐way analysis of variance (ANOVA) and Tukey's multiple comparisons test; *P < 0.05, **P < 0.01, ***P < 0.001; error bars represent mean ± SEM. Each “n” represents one mouse; CI: confidence interval. Elisabeth MMA Andriessen et al. EMBO Mol Med. 2016;emmm.201606531 © as stated in the article, figure or figure legend