A Hen in the Wolf Den: A Pathobiont Tale Matteo M. Guerrini, Alexis Vogelzang, Sidonia Fagarasan  Immunity  Volume 48, Issue 4, Pages 628-631 (April 2018) DOI: 10.1016/j.immuni.2018.04.003 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 Translocation of the Gut Commensal Bacterium Enterococcus gallinarum Triggers the Onset of Systemic Lupus Erythematosus in the (NZW × BXSB) F1 Strain of Lupus-Prone Mice The gut of lupus-prone mice is characterized by compromised barrier function, reduced mucus expression, and an imbalance of microbial diversity, resulting in bacterial translocation. In the lamina propria of the small intestine, E. gallinarum induces an increase of plasmacytoid dendritic cells (pDCs) that produce IFNα. E. gallinarum produces AhR ligands, which enhance Th17 and T follicular helper (Tfh) cell activation and differentiation. In the liver, E. gallinarum induces expression of lupus-specific autoantigens and inflammatory factors, enhancing pathogenic deposition of immune complexes in multiple organs. Immunity 2018 48, 628-631DOI: (10.1016/j.immuni.2018.04.003) Copyright © 2018 Elsevier Inc. Terms and Conditions