Genetic Linkage of Hereditary Gingival Fibromatosis to Chromosome 2p21

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Presentation transcript:

Genetic Linkage of Hereditary Gingival Fibromatosis to Chromosome 2p21 Thomas C. Hart, Debora Pallos, Donald W. Bowden, Joey Bolyard, Mark J. Pettenati, Jose R. Cortelli The American Journal of Human Genetics Volume 62, Issue 4, Pages 876-883 (April 1998) DOI: 10.1086/301797 Copyright © 1998 The American Society of Human Genetics Terms and Conditions

Figure 1 Pedigree of family segregating the HGF phenotype. Genetic haplotypes are presented for all individuals genotyped. Boxes surround alleles inherited from individual I-1. The American Journal of Human Genetics 1998 62, 876-883DOI: (10.1086/301797) Copyright © 1998 The American Society of Human Genetics Terms and Conditions

Figure 2 A, Clinical photograph (individual III-4) showing gingival fibromatosis. B, Periapical radiograph (individual III-4) showing normal level of alveolar bone. C, Histological section showing extension of epithelial rete pegs into underlying corneum (hematoxylin and eosin stain, original magnification × 100). The American Journal of Human Genetics 1998 62, 876-883DOI: (10.1086/301797) Copyright © 1998 The American Society of Human Genetics Terms and Conditions

Figure 3 Multipoint LOD-score calculations between the HGF phenotype and markers D2S392, D2S405, D2S1788, D2S1346, D2S1348, D2S119, D2S1352, D2S1337, D2S406, D2S441, and D2S1394. The multipoint LOD score is represented on the x axis. The positions of the DNA marker loci tested are located on the y axis, together with the genetic location coordinate (in centimorgans) according to the Généthon map; the zero coordinate is at the short-arm telomere (Gyapay et al. 1994). Marker D2S2739 has not been included in the multipoint analysis because its precise genetic location was not known. The American Journal of Human Genetics 1998 62, 876-883DOI: (10.1086/301797) Copyright © 1998 The American Society of Human Genetics Terms and Conditions