Armodafinil for Sarcoidosis-Associated Fatigue: A Double-Blind, Placebo-Controlled, Crossover Trial Elyse E. Lower, MD, Atul Malhotra, MD, Victoria Surdulescu,

Slides:

Advertisements

Similar presentations

Treatment of postherpetic neuralgia: a review of therapeutic options Charles E. Argoff, MD, Nathaniel Katz, MD, Miroslav Backonja, MD Journal of Pain and.

Advertisements

Comparison of the Constipation Assessment Scale and Plain Abdominal Radiography in the Assessment of Constipation in Advanced Cancer Patients Kittiphon.

Management of Phantom Pain with a Textile, Electromagnetically-Acting Stump Liner: A Randomized, Double-Blind, Crossover Study Uwe Kern, MD, Bernd Altkemper,

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Shuangbai San for Treating Primary Liver Cancer Patients With Cancer Pain Xiaowei.

Christine Miaskowski, RN, PhD, FAAN, Steven M. Paul, PhD, Bruce A

One-Year rTMS Treatment for Refractory Trigeminal Neuralgia

Chronic Pain Management in Older Adults: Special Considerations

Managing Metastatic Bone Pain: The Role of Bisphosphonates

Patient-Reported Outcomes as a Component of the Primary Endpoint in a Double-Blind, Placebo-Controlled Trial in Advanced Pancreatic Cancer S. Gail Eckhardt,

Carmelita P. Escalante, MD, Michael A. Kallen, PhD, MPH, Rosalie U

Clinical Trial Results with OROS® Hydromorphone

Managing Metastatic Bone Pain: The Role of Bisphosphonates

Wen Jing Chung, MD, MS, Gregory H. Pharo, DO

A Randomized, Double-Blind, Placebo-Controlled Study of Intrathecal Ziconotide in Adults with Severe Chronic Pain Richard L. Rauck, MD, Mark S. Wallace,

An Effective Treatment of Severe Complex Regional Pain Syndrome Type 1 in a Child Using High Doses of Intrathecal Ziconotide Michael Stanton-Hicks, MD,

Chronic Pain Management in Older Adults: Special Considerations

A Case Series of Patients Using Medicinal Marihuana for Management of Chronic Pain Under the Canadian Marihuana Medical Access Regulations Mary E. Lynch,

Opioids for Cancer Breakthrough Pain: A Pilot Study Reporting Patient Assessment of Time to Meaningful Pain Relief Giovambattista Zeppetella, FRCP Journal.

Long-Term Opioid Therapy for Chronic Noncancer Pain: A Systematic Review and Meta-Analysis of Efficacy and Safety Meredith Noble, MS, Stephen J. Tregear,

Analgesic and Sedative Effects of Melatonin in Temporomandibular Disorders: A Double-Blind, Randomized, Parallel-Group, Placebo-Controlled Study Liliane.

Pilot Randomized Controlled Trial of a Patient-Controlled Cognitive-Behavioral Intervention for the Pain, Fatigue, and Sleep Disturbance Symptom Cluster.

A Double-Blind, Placebo-Controlled, Crossover Pilot Trial With Extension Using an Oral Mucosal Cannabinoid Extract for Treatment of Chemotherapy-Induced.

David M. Simpson, MD, Lydia Estanislao, MD, Stephen J

Efficacy of Dexmethylphenidate for the Treatment of Fatigue After Cancer Chemotherapy: A Randomized Clinical Trial Elyse E. Lower, MD, Stewart Fleishman,

Fatigue in Gynecological Cancer Patients During and After Anticancer Treatment Gillian Prue, PhD, James Allen, PhD, Jacqueline Gracey, PhD, Jane Rankin,

Efficacy and Safety of the Seven-Day Buprenorphine Transdermal System in Opioid- Naïve Patients with Moderate to Severe Chronic Low Back Pain: An Enriched,

What Palliative Care-Related Problems Do Patients Experience at HIV Diagnosis? A Systematic Review of the Evidence Victoria M. Simms, MSc, Irene J. Higginson,

Bupropion for Control of Hot Flashes in Breast Cancer Survivors: A Prospective, Double-Blind, Randomized, Crossover, Pilot Phase II Trial Geila Ribeiro.

Use of the Cumulative Proportion of Responders Analysis Graph to Present Pain Data Over a Range of Cut-Off Points: Making Clinical Trial Data More Understandable

What Influences Patients’ Decisions on Artificial Hydration at the End of Life? A Q- Methodology Study Catherine Malia, MSc, Michael I. Bennett, MB, ChB,

Caffeine as an Adjuvant Therapy to Opioids in Cancer Pain: A Randomized, Double- Blind, Placebo-Controlled Trial Sang-Yeon Suh, MD, PhD, Youn Seon Choi,

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Shuangbai San for Treating Primary Liver Cancer Patients With Cancer Pain Xiaowei.

Double-Blind, Placebo-Controlled Trial of Lamotrigine in Combination with Other Medications for Neuropathic Pain Marianne Silver, MS, David Blum, MD,

Antipsychotics for Acute and Chronic Pain in Adults

A randomized, double-blind, crossover study of the use of transcutaneous spinal electroanalgesia in patients with pain from chronic critical limb ischemia

Jean-Pierre Van Buyten, MD Journal of Pain and Symptom Management

One-Year rTMS Treatment for Refractory Trigeminal Neuralgia

Redefining Appropriate Treatment Expectations

Lack of Benefit From Paracetamol (Acetaminophen) for Palliative Cancer Patients Requiring High-Dose Strong Opioids: A Randomized, Double-Blind, Placebo-Controlled,

Jodi L. Hannan, MD, Steven M. Radwany, MD, Terry Albanese, PhD

Ecological Momentary Assessment of Fatigue in Patients Receiving Intensive Cancer Therapy Eileen Danaher Hacker, PhD, APN, AOCN, Carol Estwing Ferrans,

Amitriptyline in the Treatment of Chemotherapy-Induced Neuropathic Symptoms Anna-Liisa Kautio, MD, Maija Haanpää, MD, PhD, Tiina Saarto, MD, PhD, Eija.

Barrie R. Cassileth, PhD, Andrew J. Vickers, PhD

A Pilot Cluster-Randomized Trial of a 20-Week Tai Chi Program in Elders With Cognitive Impairment and Osteoarthritic Knee: Effects on Pain and Other Health.

A Proposed Taxonomy of Terms to Guide the Clinical Trial Recruitment Process Neil A. Hagen, MD, FRCPC, Jackson S. Wu, MD, FRCPC, Carla R. Stiles, BN

Efficacy and Side Effects of Diclofenac Patch in Treatment of Patients with Myofascial Pain Syndrome of the Upper Trapezius Lin-Fen Hsieh, MD, Chang-Zern.

Robert L. Jayes, MD, Robert M. Arnold, MD, Erik K. Fromme, MD

The Impact of Symptoms, Coping Capacity, and Social Support on Quality of Life Experience Over Time in Patients with Lung Cancer Ingela Henoch, RN, PhD,

Effects of Methylphenidate on Fatigue and Depression: A Randomized, Double-Blind, Placebo-Controlled Trial Christopher W. Kerr, MD, PhD, Julie Drake,

U.S. Hospice Benefits Journal of Pain and Symptom Management

Randomized, Double-Blind, Placebo-Controlled Trial of Oral Docusate in the Management of Constipation in Hospice Patients Yoko Tarumi, MD, Mitchell P.

Which Treatment Is Better

Is the B12/CRP Index More Accurate Than You at Predicting Life Expectancy in Advanced Cancer Patients? Filipa Tavares, MD Journal of Pain and Symptom.

Development and Reliability Testing of the Victoria Bowel Performance Scale (BPS) G. Michael Downing, MD, Craig Kuziemsky, PhD, Mary Lesperance, PhD,

Comparative Efficacy of Oral Extended-Release Hydromorphone and Immediate- Release Hydromorphone in Patients with Persistent Moderate to Severe Pain: Two.

A Double-Blind, Randomized, Crossover Comparison Between Single-Dose and Double-Dose Immediate-Release Oral Morphine at Bedtime in Cancer Patients Ola.

Tomoyuki Kawada, MD Journal of Pain and Symptom Management

Gabapentin and an Opioid Combination Versus Opioid Alone for the Management of Neuropathic Cancer Pain: A Randomized Open Trial Kader Keskinbora, MD,

Nina D. Wagner-Johnston, MD, Kathryn A. Carson, ScM, Stuart A

Use of the Palliative Outcome Scale in Argentina: A Cross-Cultural Adaptation and Validation Study Jorge H. Eisenchlas, MD, MSc, Richard Harding, BSc,

Nathaniel P Katz, MD Journal of Pain and Symptom Management

Christine Miaskowski, RN, PhD, FAAN, Steven M. Paul, PhD, Bruce A

Effects of Prophylactic Subcutaneous Fentanyl on Exercise-Induced Breakthrough Dyspnea in Cancer Patients: A Preliminary Double-Blind, Randomized, Controlled.

Management of Phantom Pain with a Textile, Electromagnetically-Acting Stump Liner: A Randomized, Double-Blind, Crossover Study Uwe Kern, MD, Bernd Altkemper,

Scrambler Therapy May Relieve Chronic Neuropathic Pain More Effectively Than Guideline-Based Drug Management: Results of a Pilot, Randomized, Controlled.

Long-Term Opioid Therapy for Chronic Noncancer Pain: A Systematic Review and Meta-Analysis of Efficacy and Safety Meredith Noble, MS, Stephen J. Tregear,

Associations Between Physical Activity and Quality of Life in Cancer Patients Receiving Palliative Care: A Pilot Survey Sonya S. Lowe, MD, MSc, Sharon.

Use of Pregabalin in the Management of Chronic Uremic Pruritus

Fatigue in Gynecological Cancer Patients During and After Anticancer Treatment Gillian Prue, PhD, James Allen, PhD, Jacqueline Gracey, PhD, Jane Rankin,

Randomized Double-Blind Trial of Sublingual Atropine vs

Presentation transcript:

Armodafinil for Sarcoidosis-Associated Fatigue: A Double-Blind, Placebo-Controlled, Crossover Trial Elyse E. Lower, MD, Atul Malhotra, MD, Victoria Surdulescu, MD, Robert P. Baughman, MD Journal of Pain and Symptom Management Volume 45, Issue 2, Pages 159-169 (February 2013) DOI: 10.1016/j.jpainsymman.2012.02.016 Copyright © 2013 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 1 Flow diagram summarizing the double-blind, placebo-controlled, crossover design of the study. Overnight sleep studies followed by multiple sleep latency tests (MSLT) were performed prior to randomization and at the end of each eight-week treatment period. Journal of Pain and Symptom Management 2013 45, 159-169DOI: (10.1016/j.jpainsymman.2012.02.016) Copyright © 2013 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 2 CONSORT diagram22 detailing the outcome of studied patients. Ten patients were unable or unwilling to undergo an initial sleep study. After the initial sleep study, five patients were excluded from further study because of inadequately controlled sleep apnea or restless leg syndrome. Fourteen patients completed all 19 weeks of the study as detailed in Fig. 1. Journal of Pain and Symptom Management 2013 45, 159-169DOI: (10.1016/j.jpainsymman.2012.02.016) Copyright © 2013 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 3 The change of the Fatigue Assessment Scale (FAS) score after four or eight week of therapy compared with the baseline value (Week 1 or 11). There was a significant difference between armodafinil and placebo after eight weeks of therapy (P=0.0295). Journal of Pain and Symptom Management 2013 45, 159-169DOI: (10.1016/j.jpainsymman.2012.02.016) Copyright © 2013 U.S. Cancer Pain Relief Committee Terms and Conditions

Fig. 4 The change of the Functional Assessment of Chronic Illness Therapy—Fatigue (FACIT-F) score after four or eight week of therapy compared with the baseline value (Week 1 or 11). There was a significant difference between armodafinil and placebo after four and eight weeks of therapy (P=0.0149 and P=0.0040, respectively). Journal of Pain and Symptom Management 2013 45, 159-169DOI: (10.1016/j.jpainsymman.2012.02.016) Copyright © 2013 U.S. Cancer Pain Relief Committee Terms and Conditions