Noninvasive Diagnosis of Hepatic Fibrosis in Patients With Chronic Hepatitis C by Splenic Doppler Impedance Index  Chen–Hua Liu, Shih–Jer Hsu, Jou–Wei Lin, Juey–Jen Hwang, Chun–Jen Liu, Pei–Ming Yang, Ming–Yang Lai, Pei–Jer Chen, Jun– Herng Chen, Jia–Horng Kao, Ding–Shinn Chen  Clinical Gastroenterology and Hepatology  Volume 5, Issue 10, Pages 1199-1206.e1 (October 2007) DOI: 10.1016/j.cgh.2007.07.017 Copyright © 2007 AGA Institute Terms and Conditions

Figure 1 Flow diagram of the study. Clinical Gastroenterology and Hepatology 2007 5, 1199-1206.e1DOI: (10.1016/j.cgh.2007.07.017) Copyright © 2007 AGA Institute Terms and Conditions

Figure 2 DDU images to evaluate (A) PVVmean, (B) HARI and HAPI of the right branch of the hepatic artery, and (C) SARI and SAPI of the splenic artery near the splenic hilum. Clinical Gastroenterology and Hepatology 2007 5, 1199-1206.e1DOI: (10.1016/j.cgh.2007.07.017) Copyright © 2007 AGA Institute Terms and Conditions

Figure 3 ROC curves of regression models, SAPI, and PVVmean in predicting patients with significant hepatic fibrosis (≥F2) and cirrhosis (F4) in the training set. (A) AUCs of the regression model and SAPI were comparable in predicting patients with significant hepatic fibrosis (0.88 vs 0.87, P = .22). In addition, AUCs of the regression model and SAPI were higher than PVVmean in predicting patients with significant hepatic fibrosis (0.88 vs 0.70, P < .001, and 0.87 vs 0.70, P < .001, respectively). (B) AUCs of the regression model and SAPI were comparable in predicting patients with cirrhosis (0.92 vs 0.90, P = .12). In addition, AUCs of the regression model and SAPI were higher than PVVmean in predicting patients with significant hepatic fibrosis (0.92 vs 0.80, P < .001, and 0.90 vs 0.80, P = .03, respectively). Clinical Gastroenterology and Hepatology 2007 5, 1199-1206.e1DOI: (10.1016/j.cgh.2007.07.017) Copyright © 2007 AGA Institute Terms and Conditions

Figure 4 ROC curves of regression models, SAPI, and PVVmean in predicting patients with significant hepatic fibrosis (≥F2) and cirrhosis (F4) in the validation set. (A) AUCs of the regression model and SAPI were comparable in predicting patients with significant hepatic fibrosis (0.89 vs 0.89, P = .37). In addition, AUCs of the regression model and SAPI were higher than PVVmean in predicting patients with significant hepatic fibrosis (0.89 vs 0.74, P < .001, and 0.89 vs 0.74, P < .001, respectively). (B) AUCs of the regression model and SAPI were comparable in predicting patients with cirrhosis (0.93 vs 0.92, P = .30). In addition, AUCs of regression model and SAPI were higher than PVVmean in predicting patients with significant hepatic fibrosis (0.93 vs 0.78, P < .001, and 0.92 vs 0.78, P = .004, respectively). Clinical Gastroenterology and Hepatology 2007 5, 1199-1206.e1DOI: (10.1016/j.cgh.2007.07.017) Copyright © 2007 AGA Institute Terms and Conditions