A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order Adaikalavan.

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Presentation transcript:

A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order Adaikalavan Ramasamy, DPhil, Ivan Curjuric, MD, Lachlan J. Coin, DPhil, Ashish Kumar, MSc, Wendy L. McArdle, PhD, Medea Imboden, PhD, Benedicte Leynaert, PhD, Manolis Kogevinas, MD, Peter Schmid-Grendelmeier, MD, Juha Pekkanen, MD, Matthias Wjst, MD, Andreas J. Bircher, MD, Ulla Sovio, PhD, Thierry Rochat, MD, Anna-Liisa Hartikainen, MD, David J. Balding, DPhil, Marjo-Riitta Jarvelin, MD, Nicole Probst-Hensch, PhD, David P. Strachan, MD, Deborah L. Jarvis, MD Journal of Allergy and Clinical Immunology Volume 128, Issue 5, Pages 996-1005 (November 2011) DOI: 10.1016/j.jaci.2011.08.030 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Manhattan plots for main-effect analyses of IgE sensitization to grass and AR. Journal of Allergy and Clinical Immunology 2011 128, 996-1005DOI: (10.1016/j.jaci.2011.08.030) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Concordance in statistical significance between AR and grass sensitization for the selected loci. Each loci is represented by the SNP with the lowest P value. The direction of association is consistent between these 2 phenotypes for the loci shown here (see Table II). Journal of Allergy and Clinical Immunology 2011 128, 996-1005DOI: (10.1016/j.jaci.2011.08.030) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Regional association and forest plots for rs7775228 in the HLA region. Journal of Allergy and Clinical Immunology 2011 128, 996-1005DOI: (10.1016/j.jaci.2011.08.030) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Regional association and forest plots for rs2155219, which is near C11orf30 (chromosome 11 open reading frame 30) and LRRC32 (leucine-rich repeat containing 32). Journal of Allergy and Clinical Immunology 2011 128, 996-1005DOI: (10.1016/j.jaci.2011.08.030) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 Regional association and forest plots for rs17513503, which is near SLC25A46 and TMEM232. Journal of Allergy and Clinical Immunology 2011 128, 996-1005DOI: (10.1016/j.jaci.2011.08.030) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions